In Bacillus anthracis, an alternative to the use of chelating agents (siderophores) for acquiring iron consists in using a system of hemophores and transporter proteins for scavenging hemes from hemoglobin and delivering them into the bacterial cell. B. anthracis utilizes the siderophore-mediated way of acquiring iron predominantly at the intracellular stage of its development; the system of hemoinantly at the transporter proteins is used at the extracellular stage of anthrax infection. The structure, genetic organization and functions of the system for the heme iron acquisition in B. anthracis, understanding of which may facilitate development of new therapies for anthrax, are discussed.
在炭疽芽孢杆菌中,除了使用螯合剂(铁载体)获取铁之外,另一种方式是利用血色素蛋白和转运蛋白系统从血红蛋白中清除血红素并将其输送到细菌细胞内。炭疽芽孢杆菌在其发育的细胞内阶段主要利用铁载体介导的方式获取铁;而在炭疽感染的细胞外阶段则主要使用血色素转运蛋白系统。本文讨论了炭疽芽孢杆菌血红素铁获取系统的结构、基因组织和功能,了解这些内容可能有助于开发针对炭疽的新疗法。