碘和 TBHP 协同催化 1-(2-乙炔基芳基)丙-2-烯-1-酮的氧化串联环化反应。
Oxidative tandem annulation of 1-(2-ethynylaryl)prop-2-en-1-ones catalyzed by cooperative iodine and TBHP.
机构信息
Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle, Nanchang Hangkong University, Nanchang 330063, China.
出版信息
Chem Commun (Camb). 2019 Jan 16;55(5):667-670. doi: 10.1039/c8cc09271k. Epub 2018 Dec 19.
A new, metal-free I-catalyzed oxidative tandem annulation of 1,6-enynes by employing tert-butyl hydroperoxide (TBHP) as the oxidant and the oxygen atom resource for the synthesis of 1H-cyclopropa-[b]naphthalene-2,7-diones is developed. This reaction allows the formation of three new chemical bonds through selective radical addition across the C[triple bond, length as m-dash]C bond and tandem cyclization cascades, which features a broad 1,6-enyne scope and excellent chemo- and diastereoselectivities.
发展了一种新型的无金属 I 催化的 1,6-烯炔的氧化串联环化反应，使用叔丁基过氧化氢（TBHP）作为氧化剂和氧原子资源，用于合成 1H-环丙[a]萘-2,7-二酮。该反应通过选择性自由基加成到 C[三重键，长度为 m-dash]C 键和串联环化级联，形成三个新的化学键，具有广泛的 1,6-烯炔范围和优异的化学和非对映选择性。
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