普罗多酸：大鼠和犬体内的分析及处置研究
Prodolic acid: analysis and disposition studies in rats and dogs.
作者信息
Robinson W T, Kraml M, Greselin E, Dvornik D
出版信息
Xenobiotica. 1977 Jun;7(6):329-37. doi: 10.3109/00498257709035791.
PMID:305689
Abstract
- A specific fluorimetric method for the determination of prodolic acid in serum has been elaborated and has a limit of detection of 2 microgram/ml. 2. Common anti-inflammatory drugs do not interfere with the method. 3. In rats and dogs, prodolic acid is rapidly absorbed and has a short half-life of elimination. 4. The rate of elimination was marked by secondary rises in the blood level profile which were shown to be due enterohepatic recirculation of prodolic acid. 5. Prodolic acid is highly bound to serum protein.
摘要
- 已制定出一种用于测定血清中普罗多昔酸的特定荧光法，其检测限为2微克/毫升。2. 常用抗炎药不干扰该方法。3. 在大鼠和狗中，普罗多昔酸吸收迅速，消除半衰期短。4. 消除速率的特征是血药浓度曲线出现二次升高，这被证明是由于普罗多昔酸的肠肝循环所致。5. 普罗多昔酸与血清蛋白高度结合。
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