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表面健康的医院就诊者中乙肝病毒感染的血清学特征

Serological profile of HBV infection among apparently healthy hospital attendees.

作者信息

Adetunji Stephen Oluwasegun, Donbraye Emmanuel, Alawode-Obabiyi Lateefah, Akinniyi Oluwasola

机构信息

a Medical Microbiology and Parasitology, College of Health Sciences , Obafemi Awolowo University , Ile-Ife , Nigeria.

出版信息

J Immunoassay Immunochem. 2019;40(3):237-249. doi: 10.1080/15321819.2018.1555764. Epub 2018 Dec 20.

Abstract

Hepatitis B virus (HBV) infection has been rated 10th among the killer diseases. Occult HBV infection goes undetected with the widely used HBsAg screening in most hospital thereby encouraging progression into complications such as liver cirrhosis and hepatocellular carcinoma. This work therefore aimed at evaluating HBV serological profiles among the population of apparently healthy hospital attendees and their proportion of susceptibility to HBV infection. 239 participants were recruited for this study. Their blood samples were screened for the HBV markers - HBsAg, anti-HBs, HBeAg, anti-HBe, and anti-HBc. In conclusion, this work depicted various serological patterns of HBV infection among apparently healthy hospital attendees suggesting there are occult HBV infection and immune escape mutant in our population. It also showed that a huge number of the study population were susceptible to HBV infection.

摘要

乙型肝炎病毒(HBV)感染在致命疾病中排名第十。隐匿性HBV感染在大多数医院广泛使用的HBsAg筛查中未被发现,从而促使病情发展为肝硬化和肝细胞癌等并发症。因此,这项研究旨在评估表面健康的医院就诊人群中的HBV血清学特征及其对HBV感染的易感性比例。本研究招募了239名参与者。对他们的血样进行了HBV标志物——HBsAg、抗-HBs、HBeAg、抗-HBe和抗-HBc的筛查。总之,这项研究描绘了表面健康的医院就诊人群中HBV感染的各种血清学模式,表明我们的人群中存在隐匿性HBV感染和免疫逃逸突变体。研究还表明,大量研究人群易感染HBV。

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