β肾上腺素能受体调控的再思考。
Beta-Adrenergic Receptor Regulation Revisited.
机构信息
From the Department of Pharmacology, Columbia University, New York.
出版信息
Circ Res. 2018 Nov 9;123(11):1199-1201. doi: 10.1161/CIRCRESAHA.118.313884.
Abstract
The actions and regulation of cardiomyocyte βARs differ in several respects from the properties described for the prototypical βAR subtype; a mechanism to explain the unique properties of the βAR subtype has never been obvious. This viewpoint summarizes recent studies that identify a novel signaling paradigm for the βAR, implicating the N-terminus as a molecular determinant of βAR responsiveness.
摘要
心肌细胞 βAR 的作用和调节在几个方面不同于典型的βAR 亚型的特性；解释βAR 亚型独特特性的机制从未明显存在过。这一观点总结了最近的研究，这些研究确定了βAR 的一种新的信号传递范例，暗示 N 端是βAR 反应性的分子决定因素。
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本文引用的文献
1
Carvedilol Prevents Redox Inactivation of Cardiomyocyte Β-Adrenergic Receptors.
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2
β-adrenergic receptor O-glycosylation regulates N-terminal cleavage and signaling responses in cardiomyocytes.
Sci Rep. 2017 Aug 11;7(1):7890. doi: 10.1038/s41598-017-06607-z.
3
β-Arrestin drives MAP kinase signalling from clathrin-coated structures after GPCR dissociation.
Nat Cell Biol. 2016 Mar;18(3):303-10. doi: 10.1038/ncb3307. Epub 2016 Feb 1.
4
Glycan imaging in intact rat hearts and glycoproteomic analysis reveal the upregulation of sialylation during cardiac hypertrophy.
J Am Chem Soc. 2014 Dec 17;136(50):17468-76. doi: 10.1021/ja508484c. Epub 2014 Oct 14.
5
Crystal structures of a stabilized β1-adrenoceptor bound to the biased agonists bucindolol and carvedilol.
Structure. 2012 May 9;20(5):841-9. doi: 10.1016/j.str.2012.03.014.
6
Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.
Nature. 2007 Nov 15;450(7168):383-7. doi: 10.1038/nature06325. Epub 2007 Oct 21.
7
Adrenergic regulation of cardiac myocyte apoptosis.
J Cell Physiol. 2001 Dec;189(3):257-65. doi: 10.1002/jcp.10024.
8
Altered beta-adrenergic receptor gene regulation and signaling in chronic heart failure.
J Mol Cell Cardiol. 2001 May;33(5):887-905. doi: 10.1006/jmcc.2001.1358.
9
Interaction with beta-arrestin determines the difference in internalization behavor between beta1- and beta2-adrenergic receptors.
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10
Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice.
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