Department of General and Oncological Pulmonology, First Chair of Internal Diseases, Medical University of Lodz, Lodz, Poland.
Department of Molecular Bases of Medicine, First Chair of Internal Diseases, Medical University of Lodz, Lodz, Poland.
Adv Med Sci. 2019 Mar;64(1):85-89. doi: 10.1016/j.advms.2018.08.006. Epub 2018 Dec 17.
Pentraxin 3 (PTX-3) is an acute phase protein that belongs to the pentraxin superfamily. It is synthesized locally at the site of inflammation and its levels are related to the damage of blood vessels. There are only a few studies examining the relationship between PTX-3 and chronic obstructive pulmonary disease (COPD). The aim of this study was to evaluate the serum levels of PTX-3 and relative PTX-3 gene expression in COPD patients and their correlations with cigarette smoking history and lung function.
MATERIALS/METHODS: A total number of 34 participants were enrolled into this study. Only stable patients without comorbidities were recruited. After obtaining written informed consent all planned procedures were performed (pre- and post-bronchodilator spirometry, blood samples for PTX-3 serum levels and PTX-3 gene expression measurements, demographical data, medical history, COPD patients were also asked for CAT and MMRC questionnaires).
PTX-3 serum levels were significantly higher in the COPD group (29.22 (5.47) ng/ml vs. 14.64 (3.64) ng/ml). PTX-3 gene relative quantification (RQ) values were also significantly higher in the COPD group (0.15 (1.33) vs. -2.80 (1.99)). No differences in CRP serum levels were found between the control group and the COPD group.
Our study demonstrates that serum levels of PTX-3 and the relative expression values of its gene are elevated in COPD, and can be related to cigarette smoking history.
血清正五聚蛋白 3（PTX-3）是一种急性时相蛋白，属于五聚蛋白家族。它在炎症部位局部合成，其水平与血管损伤有关。目前仅有少数研究探讨了 PTX-3 与慢性阻塞性肺疾病（COPD）之间的关系。本研究旨在评估 COPD 患者血清 PTX-3 水平及其相对 PTX-3 基因表达，并探讨其与吸烟史和肺功能的关系。
材料/方法：本研究共纳入 34 名参与者，均为稳定期且无合并症的 COPD 患者。在获得书面知情同意后，所有计划的程序均已执行（支气管扩张剂前后肺功能检查、PTX-3 血清水平和 PTX-3 基因表达测量的血液样本、人口统计学数据、病史，COPD 患者还填写 CAT 和 MMRC 问卷）。
COPD 组的 PTX-3 血清水平明显升高（29.22（5.47）ng/ml 比 14.64（3.64）ng/ml）。PTX-3 基因相对定量（RQ）值在 COPD 组也明显升高（0.15（1.33）比-2.80（1.99））。COPD 组与对照组的 CRP 血清水平无差异。
我们的研究表明，COPD 患者血清 PTX-3 水平及其基因的相对表达值升高，可能与吸烟史有关。
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