Lechner Raimund, Helm M, Müller M, Wille T, Riesner H J, Friemert B
Department of Anaesthesiology, Intensive Care, Emergency Medicine and Pain Medicine, German Armed Forces Hospital of Ulm, Ulm, Germany
Department of Anaesthesiology, Intensive Care, Emergency Medicine and Pain Medicine, German Armed Forces Hospital of Ulm, Ulm, Germany.
J R Army Med Corps. 2019 Oct;165(5):356-359. doi: 10.1136/jramc-2018-001092. Epub 2018 Dec 19.
Animal tests are conducted in all fields of trauma research, but transferability of these data to humans is limited. For example, it is still unclear which animal species is most similar to humans in terms of physiology of blood coagulation. To improve transferability and raise awareness of the existing differences, we compared human coagulation to coagulation of different animals. Rotational thromboelastometry was used to analyse the blood of pigs, sheep, rabbits and dogs. Animal data were compared with human coagulation based on the number of significant differences of the test parameters and on a descriptive comparison of the extent of relative deviation of the single values. All animal species showed significant differences in coagulation properties when compared with humans. Coagulation parameters of dogs and sheep were on average most similar to humans. However, there is no animal which is most similar to humans concerning all aspects of coagulation. Differences in coagulation between humans and animals are significant. This must be taken into account when transferring animal test data to humans.
动物实验在创伤研究的各个领域都有开展，但这些数据向人类的可转移性是有限的。例如，就血液凝固生理学而言，哪种动物物种与人类最为相似仍不明确。为了提高可转移性并增强对现有差异的认识，我们将人类凝血与不同动物的凝血进行了比较。采用旋转血栓弹力图分析法对猪、羊、兔和狗的血液进行分析。基于测试参数的显著差异数量以及单个值相对偏差程度的描述性比较，将动物数据与人类凝血进行比较。与人类相比，所有动物物种在凝血特性方面均表现出显著差异。狗和羊的凝血参数平均而言与人类最为相似。然而，在凝血的所有方面，没有一种动物与人类最为相似。人类与动物之间的凝血差异显著。在将动物实验数据应用于人类时必须考虑到这一点。
