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青少年艾滋病干预数据协调医学试验网络：指南的基本原理与制定

Adolescent Medicine Trials Network for HIV/AIDS Interventions Data Harmonization: Rationale and Development of Guidelines.

作者信息

McCumber Micah, Cain Demetria, LeGrand Sara, Mayer Kenneth H, Murphy Debra A, Psioda Matthew A, Seña Arlene C, Starks Tyrel J, Hudgens Michael

机构信息

Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

Center for HIV Educational Studies & Training, Hunter College, New York, NY, United States.

出版信息

JMIR Res Protoc. 2018 Dec 21;7(12):e11207. doi: 10.2196/11207.

DOI:10.2196/11207
PMID:30578242
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6320398/
Abstract

BACKGROUND: The Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) research program aims to defeat the rising HIV epidemic among adolescents and young adults in the United States. OBJECTIVE: This study aims to optimize cross-study analyses and comparisons of standardized measures (variables) collected in the ATN. METHODS: Guidelines were developed for harmonizing measures to be collected across ATN studies. RESULTS: Eight domains were identified for harmonization-Demographics and Socioeconomic Characteristics, Sexual Behavior and Risk, Substance Use and Abuse, HIV-Positive Cascade, HIV-Negative Cascade, Mental Health, Social Support and Isolation, and Pre-exposure Prophylaxis Cascade. CONCLUSIONS: The collection of selected key measures in a uniform manner across studies facilitates the characterization of participant populations, comparisons between studies, and pooled analysis of data from multiple studies.

摘要

背景：青少年艾滋病干预医学试验网络（ATN）研究项目旨在战胜美国青少年和青年中不断上升的艾滋病流行趋势。 目的：本研究旨在优化对ATN中收集的标准化测量指标（变量）进行跨研究分析和比较。 方法：制定了跨ATN研究统一收集测量指标的指南。 结果：确定了八个需统一的领域——人口统计学和社会经济特征、性行为与风险、物质使用与滥用、HIV阳性转介流程、HIV阴性转介流程、心理健康、社会支持与隔离以及暴露前预防转介流程。 结论：在各项研究中以统一方式收集选定的关键测量指标，有助于描述参与人群特征、进行研究间比较以及对多项研究的数据进行汇总分析。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bbb/6320398/74f8739403a0/resprot_v7i12e11207_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bbb/6320398/74f8739403a0/resprot_v7i12e11207_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bbb/6320398/74f8739403a0/resprot_v7i12e11207_fig1.jpg

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本文引用的文献

[1]
Psychiatric Disorders, Antiretroviral Medication Adherence and Viremia in a Cohort of Perinatally HIV-Infected Adolescents and Young Adults.

Pediatr Infect Dis J. 2018-7

[2]
Drug Overdose Deaths Among Adolescents Aged 15-19 in the United States: 1999-2015.

NCHS Data Brief. 2017-8

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J Acquir Immune Defic Syndr. 2017-3-1

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PLoS Med. 2016-11-29

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AIDS Patient Care STDS. 2016-4

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Pediatrics. 2016-1

[10]
New English and Spanish social health measures will facilitate evaluating health determinants.

Health Psychol. 2014-1-20

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