Department of Applied Chemistry , China Agricultural University , Beijing 100193 , China.
J Org Chem. 2019 Jan 18;84(2):679-686. doi: 10.1021/acs.joc.8b02515. Epub 2019 Jan 7.
Phosphine-catalyzed [3+2] annulation of β-sulfonamido-substituted enones and sulfamate-derived cyclic imines has been developed, giving a series of imidazoline derivatives in moderate to excellent yields with good to excellent diastereoselectivities. A scale-up reaction worked well under mild reaction conditions. A possible mechanism was proposed on the basis of the results obtained.
膦催化的β-磺酰胺取代烯酮和磺酰胺衍生的环亚胺的[3+2]环化反应已被开发出来，在温和的反应条件下，以中等至优秀的收率和良好至优秀的非对映选择性得到一系列咪唑啉衍生物。在温和的反应条件下，放大反应也能很好地进行。根据得到的结果提出了一种可能的反应机理。
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