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挽救断指再植及血管再通:肝素溶液皮下注射的有效性

Salvaging Digital Replantation and Revascularisation: Efficiency of Heparin Solution Subcutaneous Injection.

作者信息

Alfeky Haz, McArthur Paul, Helmy Yasser

机构信息

Consultant Plastic Surgeon, Plastic Surgery Department, University Hospital Coventry and Warwickshire, Coventry, UK.

Consultant Plastic Surgery, Whiston Hospital, Liverpool, UK.

出版信息

Surg Res Pract. 2018 Nov 21;2018:1601738. doi: 10.1155/2018/1601738. eCollection 2018.

Abstract

BACKGROUND

Distal digital replantation and revascularisation remains one of the demanding microsurgical procedures due to the difficulty of vascular anastomosis. Venous congestion is the most commonly encountered problem after replantation due to the difficulty of venous anastomosis in traumatic injuries. Heparin, among other drugs, is commonly used to facilitate venous drainage and prevent thrombosis. However, systemic heparin can be contraindicated in some patients. The senior author has experience of subcutaneous heparin injection for venous congestion in thirteen patients.

METHODS

An amount of 1 ml of calcium heparin (25,000 U) was mixed in 2.4 ml of normal saline making a solution that has 1000 U per 0.1 ml. 1000 U (0.1 ml) of the solution was injected directly into the congested replanted digits. This was repeated twice daily until venous congestion improved.

RESULTS

All the congested replanted digits survived without systemic side effects. There were no local side effects of the treatment. The PT and APTT have shown slight increase but they remained within the normal range. Haemoglobin levels have dropped slightly but no patients were at any risk of developing anaemia or needed blood transfusion.

CONCLUSIONS

Subcutaneous heparin injections can salvage the replanted digits when venous congestion is a warning flag for replantation failure. It is safe and very efficient in patients where systemic heparin cannot be administered. However, this article shows the results in only thirteen patients which is a small number to show the efficacy, safety, and side effects.

摘要

背景

由于血管吻合困难,手指末节再植及血管重建仍是一项高要求的显微外科手术。静脉淤血是再植后最常见的问题,这是由于创伤性损伤中静脉吻合困难所致。除其他药物外,肝素常用于促进静脉引流并预防血栓形成。然而,在某些患者中全身使用肝素可能是禁忌的。资深作者有对13例患者皮下注射肝素治疗静脉淤血的经验。

方法

将1毫升肝素钙(25,000单位)与2.4毫升生理盐水混合,制成每0.1毫升含1000单位的溶液。将1000单位(0.1毫升)该溶液直接注射到淤血的再植手指中。每天重复两次,直至静脉淤血改善。

结果

所有淤血的再植手指均存活,且无全身副作用。治疗无局部副作用。凝血酶原时间(PT)和活化部分凝血活酶时间(APTT)略有升高,但仍在正常范围内。血红蛋白水平略有下降,但没有患者有发生贫血的风险或需要输血。

结论

当静脉淤血预示再植失败时,皮下注射肝素可挽救再植手指。在不能使用全身肝素的患者中,该方法安全且非常有效。然而,本文仅展示了13例患者的结果,数量较少,难以全面说明疗效、安全性及副作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff04/6280226/0ccfd78ad6aa/SRP2018-1601738.001.jpg

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