应激反应中促肾上腺皮质激素释放激素基因的转录调控
Transcriptional regulation of corticotropin-releasing hormone gene in stress response.
作者信息
Zhou Jiang-Ning, Fang Hui
机构信息
CAS Key Laboratory of Brain Function and Disease, School of Life Science, University of Science and Technology of China, Hefei, 230027, Anhui, PR China.
出版信息
IBRO Rep. 2018 Aug 23;5:137-146. doi: 10.1016/j.ibror.2018.08.003. eCollection 2018 Dec.
Abstract
As a central player of the hypothalamic-pituitary-adrenal (HPA) axis, the corticotropin -releasing hormone (CRH) neurons in the hypothalamic paraventricular nucleus (PVN) determine the state of HPA axis and play a key role in stress response. Evidence supports that during stress response the transcription and expression of CRH was finely tuned, which involved -element-transcriptional factor (TF) interactions and epigenetic mechanisms. Here we reviewed recent progress in CRH transcription regulation from DNA methylation to classic TFs regulation, in which a number of paired receptors were involved. The imbalance of multiple paired receptors in regulating the activity of CRH neurons indicates a possible molecular network mechanisms underlying depression etiology and directs novel therapeutic strategies of depression in the future.
摘要
作为下丘脑-垂体-肾上腺（HPA）轴的核心参与者，下丘脑室旁核（PVN）中的促肾上腺皮质激素释放激素（CRH）神经元决定了HPA轴的状态，并在应激反应中起关键作用。有证据支持，在应激反应期间，CRH的转录和表达受到精细调节，这涉及元件-转录因子（TF）相互作用和表观遗传机制。在此，我们综述了从DNA甲基化到经典TF调节的CRH转录调控的最新进展，其中涉及许多配对受体。多种配对受体在调节CRH神经元活性方面的失衡表明了抑郁症病因潜在的分子网络机制，并为未来抑郁症的新治疗策略指明了方向。
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