雄激素性脱发额部和顶部的半定量分级量表。

A semiquantitative grading scale for frontal and vertex of androgenetic alopecia.

机构信息

Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.

出版信息

Int J Dermatol. 2019 May;58(5):582-588. doi: 10.1111/ijd.14324. Epub 2018 Dec 28.

DOI:10.1111/ijd.14324

PMID:30592306

Abstract

BACKGROUND

Depending on the severity and region of baldness, numerous researchers proposed different classifications of alopecia. However, these previous classifications have some limitations. The study aimed to establish a semiquantitative grading scale for frontal and vertex androgenetic alopecia (AGA) in both males and females.

METHODS

Standardized pictures from 1,602 AGA cases were obtained. Three sets of reference photographs with different alopecia extents from scale 0 to 5 were developed with detailed description. The photographs covered the vertex, frontal of men, and vertex + frontal (V+F) area of the scalp of women. Hair density and the ratio of vellus and terminal hairs in the alopecia area were quantitatively measured by DermDOC dermoscopy. Hair coverage rate of alopecia area was calculated by Photoshop software. Multirater consensus method was used to test the reliability and validity of the alopecia scale.

RESULTS

Fleiss-Kappa coefficients of the three sets of reference photographs for interobserver analysis reached 0.81-0.89. The overall Kendall's coefficients for intraobserver assessment totaled 0.934-0.963.

CONCLUSION

This new grading scale is a more sensitive and objective quantitative grading scale for alopecia and treatment response compared with the existing classification.

摘要

背景

根据脱发的严重程度和区域，许多研究人员提出了不同的脱发分类。然而，这些之前的分类存在一些局限性。本研究旨在为男性和女性的额部和顶部雄激素性脱发（AGA）建立一种半定量分级量表。

方法

从 1602 例 AGA 病例中获取了标准化图片。开发了三套参考照片，从 0 到 5 级，具有详细的描述。这些照片涵盖了头皮的顶部、男性的额部以及女性的顶部+额部（V+F）区域。通过 DermDOC 皮肤镜对脱发区域的毛发密度和毳毛与终毛的比例进行定量测量。通过 Photoshop 软件计算脱发区域的毛发覆盖率。采用多评估者共识方法测试脱发量表的可靠性和有效性。