脂氧素 A4 是否能通过减轻促炎反应有效治疗脂肪栓塞综合征？
Is lipoxin A4 an effective treatment on fat embolism syndrome by attenuating pro-inflammatory response?
机构信息
Department of Anesthesiology, The Second Affiliated Hospital of Soochow University, No. 1055, Sanxiang Road, Suzhou 215004, China; Department of Anesthesiology, Shanghai Sixth People's Hospital Affiliated to Shanghai, Jiao Tong University, No. 600, Yishan Road, Shanghai 200233, China.
Department of Anesthesiology, Shanghai Sixth People's Hospital Affiliated to Shanghai, Jiao Tong University, No. 600, Yishan Road, Shanghai 200233, China.
出版信息
Med Hypotheses. 2019 Jan;122:176-179. doi: 10.1016/j.mehy.2018.11.019. Epub 2018 Nov 28.
Fat embolism syndrome (FES) is characterized by high mortality and lack of effective treatment, the symptomatic therapy is most used to relieve clinical symptoms. Some studies have shown that inflammation is one of the main pathogeneses of FES. Lipoxin A4 is an endogenous-derived anti-inflammatory substance which was discovered recently. It can alleviate inflammatory response and promote inflammation resolution, and is referred as brake signal of inflammation. Therefore we hypothesize that lipoxin A4 may have a remission and therapeutic effect on FES by attenuating FES-induced inflammatory responses.
脂肪栓塞综合征（FES）的特点是死亡率高且缺乏有效治疗方法，目前最常采用对症治疗来缓解临床症状。一些研究表明，炎症是 FES 的主要发病机制之一。脂氧素 A4 是最近发现的一种内源性抗炎物质，它可以减轻炎症反应并促进炎症消退，被称为炎症的制动信号。因此，我们假设脂氧素 A4 通过减轻 FES 引起的炎症反应，可能对 FES 具有缓解和治疗作用。
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