The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu 611731, China; School of Life Science and Technology, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, China.
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu 611731, China; School of Public Affairs and Administration, University of Electronic Science and Technology of China, Chengdu, China.
J Affect Disord. 2019 Mar 1;246:387-393. doi: 10.1016/j.jad.2018.12.107. Epub 2018 Dec 26.
Is it healthy to be chaotic? Recent studies have argued that mental disorders are associated with more orderly neural activities, corresponding to a less flexible functional system. These conclusions were derived from altered temporal complexity. However, the relationship between spatial complexity and health is unknown, although spatial configuration is of importance for normal brain function.
Based on resting-state functional magnetic resonance imaging data, we used Sample entropy (SampEn) to evaluate the altered spatial complexity in patients with generalized anxiety disorder (GAD; n = 47) compared to healthy controls (HCs; n = 38) and the relationship between spatial complexity and anxiety level.
Converging results showed increased spatial complexity in patients with GAD, indicating more chaotic spatial configuration. Interestingly, inverted-U relationship was revealed between spatial complexity and anxiety level, suggesting complex relationship between health and the chaos of human brain.
Anxiety-related alteration of spatial complexity should be verified at voxel level in a larger sample and compared with results of other indices to clarify the mechanism of spatial chaotic of anxiety.
Altered spatial complexity in the brain of GAD patients mirrors inverted-U relationship between anxiety and behavioral performance, which may reflect an important characteristic of anxiety. These results indicate that SampEn is a good reflection of human health or trait mental characteristic.
混乱是否健康？最近的研究表明，精神障碍与更有序的神经活动有关，这与功能系统的灵活性较低相对应。这些结论是从改变的时间复杂度中得出的。然而，尽管空间配置对于正常的大脑功能很重要，但目前尚不清楚空间复杂性与健康之间的关系。
基于静息态功能磁共振成像数据，我们使用样本熵（SampEn）来评估广泛性焦虑障碍（GAD；n=47）患者与健康对照组（HCs；n=38）之间空间复杂性的改变，以及空间复杂性与焦虑水平之间的关系。
一致的结果表明，GAD 患者的空间复杂性增加，表明空间配置更加混乱。有趣的是，空间复杂性与焦虑水平之间呈现出倒 U 型关系，表明健康与人类大脑混沌之间存在复杂的关系。
需要在更大的样本中在体素水平上验证与焦虑相关的空间复杂性改变，并与其他指标的结果进行比较，以阐明焦虑的空间混沌机制。
GAD 患者大脑中空间复杂性的改变反映了焦虑与行为表现之间的倒 U 型关系，这可能反映了焦虑的一个重要特征。这些结果表明，SampEn 是反映人类健康或特质心理特征的良好指标。
