Nadel J A
Cardiovascular Research Institute, University of California, San Francisco 94143-0130.
Am Rev Respir Dis. 1988 Dec;138(6 Pt 2):S22-3. doi: 10.1164/ajrccm/138.6_Pt_2.S22.
Airway epithelium contains multiple mechanisms for affecting airway smooth muscle tone and responsiveness. Inflammatory diseases of the airways exhibit extensive changes in the epithelium. Thus, alterations of airway epithelium may play important roles in the pathogenesis of bronchospasm in disease states.
气道上皮细胞具有多种影响气道平滑肌张力和反应性的机制。气道的炎症性疾病在上皮细胞中呈现出广泛的变化。因此,气道上皮细胞的改变可能在疾病状态下支气管痉挛的发病机制中发挥重要作用。