Kumuda Rao, Suchetha Kumari, Subhas G Babu, Urvashi A Shetty, Harshini Ullal
Department of Oral Medicine and Radiology, A B Shetty Memorial Institute of Dental Sciences, NITTE deemed to be University, Deralakatte, Mangalore.
Department of Biochemistry, K.S. Hegde medical academy, NITTE deemed to be University, Deralakatte, Mangalore.
Afr Health Sci. 2018 Jun;18(2):244-252. doi: 10.4314/ahs.v18i2.7.
Stress is an undesirable or health threatening response of the body, which is brought on by deleterious external influences (stressors). Objective measurement of psychosocial stress helps in assessment of pivotal role of stress in precipitation of multitude of health problems and a solution to the same. Salivary biomarkers are suggested to provide a reliable and non-invasive method for the estimation of these general health problems. Salivary cortisol is such biomarker used as tool in the examination of human physiological stress response. Post-menopausal women show an increase in stress levels and hence suffer with multiple health related problems. Hence the present study aimed to estimate salivary cortisol levels in post-menopausal women with clinically diagnosed psychosomatic disorder/disorders of the head and neck region, so as to establish salivary cortisol as a biochemical indicator of stress.
Thorough intra-oral and extra-oral examination was performed to check for the presence of psychosomatic disorder of head and neck. Unstimulated saliva was collected from 100 post-menopausal women with and 100 without clinically diagnosed psychosomatic disorder/disorders through 'Spit Technique'. Salivary cortisol was estimated using ELISA method.
The results were statistically significant as they showed that the salivary cortisol was in higher levels in post- menopausal women with clinically diagnosed psychosomatic disorder/disorders.
The geriatric patients feel that they have very little skills or resources to deal with the high levels of stress that they are experiencing and hence suffer from lack of self-worth. The results of this study recommend that stress evaluation should be done on a regular basis for all post- menopausal women. For individuals who do not reveal their psychological distress, salivary analysis of cortisol may be used as an aid to diagnose their situation in conjunction with clinical diagnosis.
压力是身体的一种不良或威胁健康的反应，由有害的外部影响（压力源）引发。客观测量心理社会压力有助于评估压力在引发众多健康问题中的关键作用，并找到解决办法。唾液生物标志物被认为可为评估这些一般健康问题提供一种可靠且非侵入性的方法。唾液皮质醇就是这样一种生物标志物，用作检测人类生理应激反应的工具。绝经后女性的压力水平会升高，因此会出现多种与健康相关的问题。因此，本研究旨在估计临床诊断患有身心障碍/头颈部疾病的绝经后女性的唾液皮质醇水平，以便将唾液皮质醇确立为压力的生化指标。
进行全面的口腔内和口腔外检查，以检查是否存在头颈部身心障碍。通过“吐口水技术”从100名临床诊断患有身心障碍和100名未患身心障碍的绝经后女性中收集非刺激性唾液。使用酶联免疫吸附测定法（ELISA）估计唾液皮质醇水平。
结果具有统计学意义，因为它们表明临床诊断患有身心障碍的绝经后女性的唾液皮质醇水平较高。
老年患者觉得他们几乎没有技能或资源来应对他们正在经历的高水平压力，因此缺乏自我价值感。本研究结果建议应对所有绝经后女性定期进行压力评估。对于那些未表露心理困扰的个体，唾液皮质醇分析可作为辅助手段，结合临床诊断来诊断他们的情况。
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