血清尿酸与高危妊娠：晚期孕妇中一种引人关注的相关性。
Serum uric acid and high-risk pregnancy: an intriguing correlation in advanced pregnant women.
作者信息
Peng You-Fan, Su Xiang-Hui, Han Man-Man, Zhu Xiang-Yun, Li Ling
机构信息
Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.
Department of Endocrinology, The First Affiliated Hospital of the Medical College, Shihezi University, Shihezi 832003, China.
出版信息
Ann Transl Med. 2018 Dec;6(23):451. doi: 10.21037/atm.2018.11.03.
BACKGROUND
The aim of our study is to explore the relationship between serum uric acid (UA) and high-risk pregnancy (HRP) in advanced pregnant women.
METHODS
The study included 226 advanced pregnant women (≥35 years), and the HRP score were assessed according to China HRP score standards.
RESULTS
All data were separated into the three groups according to HRP score, we observed significant increases of serum UA concentrations between the three groups (207.51±42.45; 226.65±45.42 and 228.27±49.70 µmol/L, P=0.017). Notably, serum UA concentrations were found to be positive correlated with HRP score (r=0.165, P=0.013) in advanced pregnant women. Serum UA was independent correlated with HRP score (beta =0.164, P=0.009) in multiple linear regression analysis.
CONCLUSIONS
We conclude that serum UA is correlated with HRP score, and increased serum UA levels may herald HRP in advanced pregnant women.
背景
我们研究的目的是探讨晚期孕妇血清尿酸（UA）与高危妊娠（HRP）之间的关系。
方法
该研究纳入了226名晚期孕妇（≥35岁），并根据中国高危妊娠评分标准评估高危妊娠评分。
结果
根据高危妊娠评分将所有数据分为三组，我们观察到三组之间血清尿酸浓度显著升高（207.51±42.45；226.65±45.42和228.27±49.70µmol/L，P=0.017）。值得注意的是，在晚期孕妇中发现血清尿酸浓度与高危妊娠评分呈正相关（r=0.165，P=0.013）。在多元线性回归分析中，血清尿酸与高危妊娠评分独立相关（β=0.164，P=0.009）。
结论
我们得出结论，血清尿酸与高危妊娠评分相关，血清尿酸水平升高可能预示晚期孕妇发生高危妊娠。
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