Department of Nephrology, Princess Alexandra Hospital, Brisbane, Australia; Faculty of Medicine, University of Queensland, Brisbane, Australia.
Division of Nephrology, University Health Network, Toronto, Ontario, Canada; Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Kidney Int. 2019 Jan;95(1):38-49. doi: 10.1016/j.kint.2018.09.016.
Choosing the optimal hemodialysis vascular access for the elderly patient is best achieved by a patient-centered coordinated multidisciplinary team approach that aligns the patient's end-stage kidney disease Life-Plan, i.e., the individual treatment approach (supportive care, time-limited or long-term kidney replacement therapy, or combination thereof) and selection of dialysis modality (peritoneal dialysis versus hemodialysis) with the most suitable dialysis access. Finding the right balance between the patient's preferences, the likelihood of access function and survival, and potential complications in the context of available resources and limited patient survival can be extremely challenging. The framework for choosing the most appropriate vascular access for the elderly presented in this review considers the individual end-stage kidney disease Life-Plan, the patient life expectancy, the likelihood of access function and survival, the timing of dialysis relative to access placement, prior access history, and patient preference. This complex decision-making process should be dynamic in order to accommodate patients' changing needs and life and health circumstances. Effective and timely communication between the patient, their caregivers, and treating team is key to delivering truly patient-centered care. Delivering this care also requires overcoming the limitations of the currently available evidence that is predominantly based on observational data with its inherent risks of bias. While challenging, future randomized controlled studies exploring the risks, benefits, costs, and timing of placement of available access types in the elderly are required to help us "get it right" for our patients.
为老年患者选择最佳的血液透析血管通路,最好采用以患者为中心的多学科协作团队方法,使患者的终末期肾病生命计划(即个体化治疗方法(支持性治疗、有限期或长期肾脏替代治疗或两者的结合)和透析方式(腹膜透析与血液透析)与最合适的透析通路相匹配。在现有资源和有限的患者生存情况下,在患者偏好、通路功能和生存的可能性以及潜在并发症之间找到适当的平衡极具挑战性。本综述中提出的为老年人选择最合适血管通路的框架考虑了个体终末期肾病生命计划、患者预期寿命、通路功能和生存的可能性、相对于通路放置的透析时机、既往通路史和患者偏好。这个复杂的决策过程应该是动态的,以适应患者不断变化的需求和生活健康情况。患者、其护理人员和治疗团队之间的有效和及时沟通是提供真正以患者为中心的护理的关键。提供这种护理还需要克服当前主要基于观察性数据的证据的局限性,这些数据存在固有偏倚风险。虽然具有挑战性,但需要未来进行探索现有各种类型通路的放置的风险、益处、成本和时机的随机对照研究,以帮助我们为患者“做正确的事”。