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手术方式对切口疝修补术后晚期复发的影响

The Impact of Surgical Approach on Late Recurrence in Incisional Hernia Repair.

作者信息

Yoo Andrew, Corso Katherine, Chung Gary, Sheng Rubin, Schmitz Niels-Derrek

机构信息

Medical Devices Epidemiology, Johnson & Johnson, Inc. New Brunswick, New Jersey, USA.

Medical Safety, Ethicon, Inc., Somerville, New Jersey, USA.

出版信息

JSLS. 2018 Oct-Dec;22(4). doi: 10.4293/JSLS.2018.00053.

Abstract

BACKGROUND AND OBJECTIVES

We conducted a retrospective, observational study to compare real-world recurrence rates for different surgical approaches after incisional hernia mesh repair.

METHODS

Two large US insurance claims databases, Truven Commercial Claims (CCAE) and Medicare Supplemental (MDCR), were evaluated for the period from 2009 to 2015. The first incisional hernia repair with mesh for patients 21 years or older was identified (INDEX). One-year continuous enrollment before INDEX was required. Mesh and approach (OPEN, laparoscopic [LAP], and conversion [CONV]) were identified with the use of CPT-4/ICD-9 codes. Recurrence was defined as a second incisional hernia repair 31 days or longer after INDEX. Kaplan-Meier (KM) estimates and Cox models were used to analyze the effect of approach on recurrence.

RESULTS

A total of 68,560 patients were identified for CCAE (78.7%) and MDCR (21.3%) with a mean (SD) age of 55.3 (12.8) years. The majority of procedures were OPEN (80.1%) followed by LAP (16.3%) and CONV (3.6%). OPEN had fewer female patients 53.7% compared with LAP (62.1%) and CONV (62.2%). CONV represented more inpatient (51.9%) procedures compared with LAP (41.0%) and OPEN (27.3%). Starting at 2 years post-INDEX, LAP (5.1%, 95% confidence interval [CI] 4.5%-5.6%) had lower KM estimates compared with OPEN (5.9%, 95% CI 5.7%-6.2%]); after 3 years, LAP (6.8%, 95% CI 6.2%-7.5%]) had lower estimates than both OPEN (7.9%, 95% CI 7.6%-8.3%) and CONV (9.3%, 95% CI 7.6%-11.0%). After controlling for confounders, the risk was lower for LAP compared with OPEN (hazard ratio 0.839, 95% CI 0.752-0.936) and CONV (hazard ratio 0.808, 95% CI 0.746-0.875), while OPEN and CONV were not significantly different from each other.

CONCLUSION

Successful laparoscopic surgery incisional hernia mesh repair was associated with decreased risk of recurrence compared with OPEN and CONV.

摘要

背景与目的

我们开展了一项回顾性观察研究,以比较切口疝补片修补术后不同手术方式的实际复发率。

方法

对美国两个大型保险理赔数据库,即Truven商业理赔数据库(CCAE)和医疗保险补充数据库(MDCR)在2009年至2015年期间的数据进行评估。确定21岁及以上患者首次使用补片进行的切口疝修补手术(INDEX)。要求在INDEX之前有一年的连续参保记录。通过CPT - 4/ICD - 9编码确定补片和手术方式(开放手术[OPEN]、腹腔镜手术[LAP]和中转手术[CONV])。复发定义为INDEX术后31天或更长时间进行的第二次切口疝修补手术。采用Kaplan - Meier(KM)估计法和Cox模型分析手术方式对复发的影响。

结果

在CCAE数据库中确定了68,560例患者(占78.7%),在MDCR数据库中确定了14,720例患者(占21.3%),平均(标准差)年龄为55.3(12.8)岁。大多数手术为开放手术(80.1%),其次是腹腔镜手术(16.3%)和中转手术(3.6%)。开放手术的女性患者较少,占53.7%,而腹腔镜手术为(62.1%),中转手术为(62.2%)。中转手术的住院手术比例(51.9%)高于腹腔镜手术(41.0%)和开放手术(27.3%)。从INDEX术后2年开始,腹腔镜手术的KM估计复发率(5.1%,95%置信区间[CI] 4.5% - 5.6%)低于开放手术(5.9%,95% CI 5.7% - 6.2%);3年后,腹腔镜手术的估计复发率(6.8%,95% CI 6.2% - 7.5%)低于开放手术(7.9%,95% CI 7.6% - 8.3%)和中转手术(9.3%,95% CI 7.6% - 11.0%)。在控制混杂因素后,腹腔镜手术的复发风险低于开放手术(风险比0.839,95% CI 0.752 - 0.936)和中转手术(风险比0.808,95% CI 0.746 - 0.875),而开放手术和中转手术之间无显著差异。

结论

与开放手术和中转手术相比,成功的腹腔镜切口疝补片修补术与较低的复发风险相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c386/6305066/e5f8b2a0ba7e/jls0201637330001.jpg

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