School of Life Science, Beijing Institute of Technology, Beijing, 100081, People's Republic of China.
College of Life Sciences & Research Center for Resource Peptide Drugs, Shaanxi Engineering & Technological Research Center for Conversation & Utilization of Regional Biological Resources, Yanan University, Yanan, 716000, People's Republic of China.
Psychopharmacology (Berl). 2019 Apr;236(4):1323-1333. doi: 10.1007/s00213-018-5138-7. Epub 2019 Jan 4.
Hippocampal neurogenesis has been widely considered as one of the potential biological mechanisms for the treatment of depression caused by chronic stress. Many natural products have been reported to be beneficial for neurogenesis.
The present study is designed to investigate the effect of dragon's blood extract (DBE) and its biologically active compound, pterostilbene (PTE), on hippocampal neurogenesis.
The male Sprague-Dawley (SD) rats were used in this study, which were maintained on the normal, DBE and PTE diet groups for 4 weeks before dissection in the normal rat model and behavioral testing in the CUS depression rat model. Meanwhile, DMI-treated rats are subcutaneously injected with DMI (10 mg/kg, i.p.).
Results revealed that DBE and PTE have the ability to promote hippocampal neurogenesis. DBE and PTE also promoted the proliferation of neural stem cells isolated from the brain of suckling rats. Oral administration of DBE and PTE induced the proliferation, migration, and differentiation of neural progenitor cells (NPCs) in chronic unexpected stressed (CUS) model rats, and improved the behavioral ability and alleviated depress-like symptoms of CUS rats. It was also observed that PTE treatment significantly induced the expression of neurogenesis-related factors, including BDNF, pERK, and pCREB.
Oral administration of PTE could affect neurogenesis and it is likely to be achieved via BDNF/ERK/CREB-associated signaling pathways.
海马神经发生被广泛认为是治疗慢性应激引起的抑郁症的潜在生物学机制之一。许多天然产物已被报道对神经发生有益。
本研究旨在探讨龙血提取物（DBE）及其生物活性化合物紫檀芪（PTE）对海马神经发生的影响。
本研究使用雄性 Sprague-Dawley（SD）大鼠，在正常、DBE 和 PTE 饮食组中饲养 4 周，然后在正常大鼠模型中进行解剖和行为测试，在慢性不可预测应激（CUS）抑郁大鼠模型中进行行为测试。同时，DMI 处理的大鼠皮下注射 DMI（10mg/kg，ip）。
结果表明，DBE 和 PTE 具有促进海马神经发生的能力。DBE 和 PTE 还促进了从乳鼠脑中分离的神经干细胞的增殖。DBE 和 PTE 的口服给药诱导慢性不可预测应激（CUS）模型大鼠中神经祖细胞（NPC）的增殖、迁移和分化，并改善 CUS 大鼠的行为能力和缓解抑郁样症状。还观察到 PTE 处理显著诱导了神经发生相关因子的表达，包括 BDNF、pERK 和 pCREB。
口服 PTE 可以影响神经发生，可能是通过 BDNF/ERK/CREB 相关信号通路实现的。
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