Bezborodova O A, Alekseenko I V, Nemtsova E R, Pankratov A A, Filyukova O B, Yakubovskaya R I, Kostina M B, Potapov V K, Sverdlov E D
Moscow Cancer Research Institute, Branch of the National Medical Research Center of Radiology, Ministry of Health of the Russian Federation, Moscow, 125284, Russia.
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.
Dokl Biochem Biophys. 2018 Nov;483(1):326-328. doi: 10.1134/S1607672918060091. Epub 2019 Jan 3.
In this study, we evaluated the antitumor activity of a gene therapy complex in which the tumor-specific control of the expression of the effector suicide gene FCU1 was performed using a two-vector system based on the site-specific Cre-LoxP recombinase system. The complex of interest showed a high therapeutic potential in a mouse colon adenocarcinoma model.
在本研究中，我们评估了一种基因治疗复合物的抗肿瘤活性，其中使用基于位点特异性Cre-LoxP重组酶系统的双载体系统对效应自杀基因FCU1的表达进行肿瘤特异性控制。在小鼠结肠腺癌模型中，该感兴趣的复合物显示出较高的治疗潜力。
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