二亚硝基铁配合物（一氧化氮供体）对人成纤维细胞代谢过程的影响
Effect of Dinitrosyl Iron Complexes (NO Donors) on the Metabolic Processes in Human Fibroblasts.
作者信息
Gizatullin A R, Akentieva N P, Sanina N A, Shmatko N Yu, Goryachev N S, Shkondina N I, Prichodchenko T R, Zhelev N, Aldoshin S M
机构信息
Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia.
Moscow State University, Moscow, 119991, Russia.
出版信息
Dokl Biochem Biophys. 2018 Nov;483(1):337-340. doi: 10.1134/S1607672918060133. Epub 2019 Jan 3.
The results of the study of the effect of mononuclear dinitrosyl iron complexes (DNICs) with functional sulfur-containing ligands (NO donors) on the cell viability and metabolism of human lung fibroblasts are presented, and the efficiency of their action is evaluated. It was shown that cationic DNICs increased the cell viability of fibroblasts and demonstrated the cytoprotective properties. Fluorescent analysis revealed that the DNICs compounds decrease the mitochondrial membrane potential but do not have a significant effect on the level of glutathione and reactive oxygen species in fibroblasts. It is assumed that the DNICs have the therapeutic potential for treating cardiovascular diseases.
本文展示了含功能性含硫配体（一氧化氮供体）的单核二亚硝基铁配合物（DNICs）对人肺成纤维细胞活力和代谢影响的研究结果，并评估了其作用效率。结果表明，阳离子DNICs可提高成纤维细胞的活力，并具有细胞保护特性。荧光分析显示，DNICs化合物可降低线粒体膜电位，但对成纤维细胞中的谷胱甘肽水平和活性氧没有显著影响。据推测，DNICs具有治疗心血管疾病的潜力。
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