[Age-related clinical characteristics and prognosis in non-senile adults with acute myeloid leukemia].

To explore age-related clinical characteristics, early responses and outcomes in non-senile adults with de novo acute myeloid leukemia (AML). Data of consecutive cases of 18-65 years adults with de novo AML (non-acute promyelocytic leukemia) were reviewed retrospectively. Clinical characteristics at diagnosis, early responses and outcomes across different age groups of patients were analyzed. 1 097 patients were enrolled. 591 (53.9%) were male. Median age was 42 years. Increasing age was significantly associated with decreasing WBC count (=0.003), increasing PLT count (=0.034), lower blast proportions in bone marrow (=0.021). The incidence of NPM1(+)/FLT3-ITD(-) increased with age (<0.001). Multivariate analyses showed that increasing age was associated with low probabilities of achieving morphologic leukemia free state (MLFS) (=0.053) and complete remission (CR) (=0.004) and poor overall survival (OS) (=0.070) in the whole patients population. However, increasing age was not associated with low MLFS rate and poor OS, except low CR rate (=0.075) in those receiving standard induction regimen instead of low-intensity regimen. There were significant differences on clinical characteristics, cytogenetics and molecular genetics across different age groups in non-senile adults with de novo AML. In the patients receiving standard induction regimen, age was not associated with MLFS rate and OS.