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前庭刺激可否用于治疗肥胖症?:针对耳石器的前庭刺激可能会重新平衡能量稳态,从而引发更苗条的身体形态,进而治疗代谢综合征。

Can Vestibular Stimulation be Used to Treat Obesity?: Vestibular stimulation targeting the otoliths could rebalance energy homeostasis to trigger a leaner body habitus and thus treat metabolic syndrome.

机构信息

Center for Brain and Cognition, UC San Diego, Mandler Hall, 9500 Gilman Drive, La Jolla CA, 92093, US.

出版信息

Bioessays. 2019 Feb;41(2):e1800197. doi: 10.1002/bies.201800197. Epub 2019 Jan 7.

Abstract

It is hypothesized that repeated, non-invasive stimulation of the vestibular (balance) system, via a small electrical current to the skin behind the ears, will cause the brain centers that control energy homeostasis to shift the body toward a leaner physique. This is because these centers integrate multiple inputs to, in effect, fix a set-point for body fat, which though difficult to alter is not immutable. They will interpret repeated stimulation of the parts of the vestibular system that detect acceleration as a state of chronic activity. During such a physiologically challenging time it is preferable, from an energy homeostasis viewpoint, to both utilize fat reserves, and reduce the volume of these reserves and thus the energy cost of carrying them around. Hence, this type of vestibular stimulation could potentially be a therapeutic option for metabolic syndrome disorders such as obesity. This hypothesis is eminently testable via a clinical trial.

摘要

据推测,通过在耳朵后面的皮肤上施加微弱电流对前庭(平衡)系统进行反复、非侵入性的刺激,将导致控制能量平衡的大脑中枢使身体向更苗条的体型转变。这是因为这些中枢整合了多种输入,实际上为身体脂肪设定了一个设定点,尽管难以改变,但并非不可改变。它们将把对检测加速度的前庭系统部分的重复刺激解释为慢性活动状态。在这种具有生理挑战性的时期,从能量平衡的角度来看,最好是利用脂肪储备,并减少这些储备的体积,从而降低携带它们的能量成本。因此,这种类型的前庭刺激可能是治疗代谢综合征疾病(如肥胖症)的一种选择。通过临床试验可以很好地验证这一假设。

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