抗癫痫药物和一氧化氮前体可能对类中风发作有益。
Antiepileptics and NO-precursors may be beneficial for stroke-like episodes.
作者信息
Finsterer Josef
机构信息
Krankenanstalt Rudolfstiftung, Messerli Institute, Veterinary University of Vienna, Postfach 20, 1180 Vienna, Austria.
出版信息
eNeurologicalSci. 2018 Dec 17;14:38-39. doi: 10.1016/j.ensci.2018.12.003. eCollection 2019 Mar.
Abstract
Pathogenesis and management of stroke-like episodes in mitochondrial disorders is under debate and no consensus has been reached thus far how this phenomenon should be managed. Frequently applied are nitric oxide (NO) precursors but a well-designed study confirming the effectiveness of such an approach is lacking. Administration of antiepileptic drugs can be meaningful if there is paroxysmal activity on EEG or if a patient presents with seizures. The case reported by Sakai et al. suggests that administration of antiepileptic drugs for a stroke-like episode may be beneficial even in the absence of seizures or paroxysmal EEG activity.
摘要
线粒体疾病中类中风发作的发病机制和管理仍存在争议，迄今为止，对于如何处理这一现象尚未达成共识。常用的是一氧化氮（NO）前体，但缺乏一项精心设计的研究来证实这种方法的有效性。如果脑电图有阵发性活动或患者出现癫痫发作，使用抗癫痫药物可能是有意义的。酒井等人报告的病例表明，即使在没有癫痫发作或脑电图阵发性活动的情况下，使用抗癫痫药物治疗类中风发作可能也是有益的。
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