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基于聚合物平台制作的级联微环生物传感器。

Cascaded-Microrings Biosensors Fabricated on a Polymer Platform.

机构信息

School of Physics and Optoelectronic Engineering, Dalian University of Technology, Dalian 116023, China.

Photonics Research Group, Department of Information and Technology, Ghent University, 9000 Ghent, Belgium.

出版信息

Sensors (Basel). 2019 Jan 6;19(1):181. doi: 10.3390/s19010181.

Abstract

Polymer-based single-microring biosensors usually have a small free spectral range (FSR) that hampers the tracing of the spectrum shifting in the measurement. A cascade of two microring resonators based on the Vernier effect, is applied in this article in order to make up for this defect. A small FSR difference between the reference microring and the sensing microring is designed, in order to superpose the periodic envelope signal onto the constituent peaks, which makes it possible to continuously track the spectrum of the sensor. The optical polymer material, Ormocore, which has a large transparent window, is used in the fabrication. The biosensor is fabricated by using an UV-based soft imprint technique, which is considered to be cost-effective and suitable for mass production. By optimizing the volume ratio of Ormocore and the maT thinner, the device can be fabricated almost without a residual layer. The device works at a wavelength of 840 nm, where water absorption loss is much lower than at the infrared wavelengths. A two-step fitting method, including single-peak fitting and whole-envelope fitting, is applied in order to trace the spectral shift accurately. Finally, the two-cascaded-microrings biosensor is characterized, and the obtained FSR is 4.6 nm, which is 16 times larger than the FSR of the single microring biosensor demonstrated in our previous work. Moreover, the sensitivity can also be amplified by 16-fold, thanks to the Vernier effect.

摘要

基于聚合物的单微环生物传感器通常具有较小的自由光谱范围(FSR),这阻碍了在测量中对光谱移动的跟踪。本文应用了基于 Vernier 效应的两个串联微环谐振器,以弥补这一缺陷。设计了参考微环和传感微环之间的小 FSR 差异,以便将周期性包络信号叠加到组成峰上,从而可以连续跟踪传感器的光谱。所使用的光学聚合物材料 Ormocore 具有较大的透明窗口。该生物传感器是通过使用基于 UV 的软压印技术制造的,这种技术具有成本效益,适合大规模生产。通过优化 Ormocore 和 maT 稀释剂的体积比,可以几乎没有残留层地制造该器件。该器件在 840nm 的波长下工作,在该波长下水吸收损耗比在红外波长下低得多。应用了两步拟合方法,包括单峰拟合和整体包络拟合,以准确跟踪光谱移动。最后,对双串联微环生物传感器进行了特性描述,得到的 FSR 为 4.6nm,比我们之前工作中演示的单微环生物传感器的 FSR 大 16 倍。此外,由于 Vernier 效应,灵敏度也可以放大 16 倍。

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