Department of Women, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Piazza L. Miraglia, 2, 80138, Naples, Italy.
Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, University of Campania "Luigi Vanvitelli", Piazza L. Miraglia, 2, 80138, Naples, Italy.
Syst Rev. 2019 Jan 8;8(1):9. doi: 10.1186/s13643-018-0934-z.
Palmitoylethanolamide (PEA) belong to endocannabinoid family, a group of fatty acid amides. PEA has been proven to have analgesic and anti-inflammatory activity and has been used in several controlled studies focused on the management of chronic pain among adult patients with different underlying clinical conditions.
METHODS/DESIGN: A literature search will be performed using PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials (CENTRAL). The population will be patients who have chronic pain, the intervention will be the administration of PEA alone or in combination with other drugs for the pain management; the comparison will be the standard therapy in accordance with the current guidelines for the treatment of pain. The Outcomes will be the reduction of pain not restricted to specific scales laying out the pain outcome data described in the included studies.
This scoping review aims to describe the clinical applications of the PEA in chronic pain management and its outcome.
Open Science Framework https://osf.io/74tmx/ .
棕榈酸乙醇酰胺(PEA)属于内源性大麻素家族,是一类脂肪酸酰胺。已有研究证实 PEA 具有镇痛和抗炎活性,并已在多项针对不同基础临床状况的成年慢性疼痛患者管理的对照研究中得到应用。
方法/设计:将通过 PubMed、EMBASE 和 Cochrane 中央对照试验注册中心(CENTRAL)进行文献检索。研究对象为患有慢性疼痛的患者,干预措施为单独给予 PEA 或与其他药物联合用于疼痛管理;对照组为根据当前疼痛治疗指南的标准治疗。主要结局为疼痛缓解,不限于特定量表,列出纳入研究中描述的疼痛结局数据。
本范围综述旨在描述 PEA 在慢性疼痛管理中的临床应用及其结局。
Open Science Framework https://osf.io/74tmx/ 。