治疗方式对 T1/T2 口咽癌患者慢性阿片类药物使用的影响。

Effect of treatment modality on chronic opioid use in patients with T1/T2 oropharyngeal cancer.

机构信息

Department of Otolaryngology-Head and Neck Surgery, University of Missouri School of Medicine, Columbia, Missouri.

出版信息

Head Neck. 2019 Apr;41(4):892-898. doi: 10.1002/hed.25482. Epub 2019 Jan 10.

DOI:10.1002/hed.25482

PMID:30629308

Abstract

BACKGROUND

The effect of treatment modality on long-term opioid dependence in patients with oropharyngeal cancer has not been reported.

METHODS

A retrospective cohort of 122 patients with T1/T2 oropharyngeal cancer undergoing treatment was generated. Risk factors associated with chronic opioid use were investigated by univariate and multivariate analyses.

RESULTS

The prevalence of chronic opioid use was 45.9%. On multivariate analysis, primary nonsurgical treatment (odds ratio [OR] 4.5, 95% confidence interval [CI]: 1.7-11.4), pretreatment opioid use (OR 14.9, 95% CI: 3.5-62.5), psychiatric disorder (OR 4.3, 95% CI: 1.03-18.5), alcohol use (OR 2.6, 95% CI: 1.03-6.5), and younger age (OR 1.1, 95% CI: 1.02-1.11) were significantly associated with chronic opioid use.

CONCLUSION

Primary nonsurgical treatment, younger age, pretreatment opioid use, alcohol use, and psychiatric disorder were independently associated with an increased risk of chronic opioid use. Preventative strategies should be especially focused toward these patients to reduce their risk of long-term opioid use.

摘要

背景

治疗方式对口咽癌患者长期阿片类药物依赖的影响尚未报道。

方法

生成了 122 例 T1/T2 口咽癌接受治疗的回顾性队列。通过单因素和多因素分析研究了与慢性阿片类药物使用相关的风险因素。

结果

慢性阿片类药物使用的患病率为 45.9%。多因素分析显示，非手术主要治疗（比值比 [OR] 4.5，95%置信区间 [CI]：1.7-11.4）、治疗前阿片类药物使用（OR 14.9，95% CI：3.5-62.5）、精神障碍（OR 4.3，95% CI：1.03-18.5）、酒精使用（OR 2.6，95% CI：1.03-6.5）和年龄较小（OR 1.1，95% CI：1.02-1.11）与慢性阿片类药物使用显著相关。