变构开关引发序列特异性 DNA 识别。
An Allosteric Switch Primes Sequence-Specific DNA Recognition.
机构信息
Department of Chemistry, University of Washington, Seattle, Washington 98195-1700, USA.
Department of Chemistry, University of Washington, Seattle, Washington 98195-1700, USA.
出版信息
Cell. 2019 Jan 10;176(1-2):4-6. doi: 10.1016/j.cell.2018.12.020.
Abstract
Regulation of protein-DNA binding specificity occurs through myriad mechanisms. Boudet et al. discover yet a new form of specificity through allosteric regulation, an ATP-induced structural switch that mediates specific DNA recognition in an archaeoeukaryotic primase.
摘要
蛋白质与 DNA 结合特异性的调节是通过无数种机制实现的。Boudet 等人通过别构调控发现了一种新的特异性形式，即 ATP 诱导的结构开关，该开关介导古核真核引物酶中特定的 DNA 识别。
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