[川芎嗪注射液对新生儿硬肿症患儿血清胱抑素C水平的影响]

[Effects of Ligustrazine Injection on Serum Cys C Level in Scierema Neonatorum Children Patients].

作者信息

Ren Qing, Jiang Jing-Hui, Zhang Yong-Jun, Yang Qiao-Zhi

出版信息

Zhongguo Zhong Xi Yi Jie He Za Zhi. 2016 Aug;36(8):908-911.

Abstract

Objective To observe the effects of Ligustrazine Injection (LI) on serum cystatin C (Cys C) level in sclerema neonatorum (SN) children patients. Methods Totally 69 SN children patients were recrui- ted as the SN group, 39 with mild SN and 30 with moderate-severe SN. Another 30 neonates were recruited as a control group. Mild SN children patients and moderate-severe SN children patients were respectively assigned to the treatment group and the routine group according to random digit table. Children patients in the routine group received routine supportive treatment and symptomatic treatment, while those in the treatment group were additionally injected with LI (6 mg/kg, adding in 30 mL 5% glucose injection; once per day). All treatment lasted for 7 successive days. Serum level of Cys C, blood urea nitrogen (BUN) , and creatinine (Cr) were detected. The abnormality rate of Cys C, BUN, and Cr was respectively calculated, and their correlations analyzed. Meanwhile, scleroma subsidence time was observed in each group. Results The serum level of Cys C was obviously elevated more in the SN group than in the control group (t =10. 55, P <0. 01). There was no statistical difference in serum level of BUN or Cr between the control group and the SN group (t =1.50, 1. 73; P >0. 05). Serum Cys C level obviously increased in moderate-severe SN children patients than in mild SN children patients (t =2. 11 , P <0. 05); serum levels of BUN and Cr showed increasing tendency in moderate-severe SN children patients and mild SN children patients, but with no statistical difference (t =2. 07, 1. 92; P >0. 05). Linear correlation showed that serum Cys C level was respectively positively correlated with serum BUN level and serum Cr level in the SN group (r =0. 314,0. 287,P <0. 05). The abnormality rate of serum Cys C, BUN, and Cr was 72. 5% (50/69), 27. 5% (19/69), and 36. 2% (25/69), respectively. The abnormality rate of serum Cys C was significantly higher than that of BUN or Cr (x² =41. 04; P <0. 01). Compared with the routine group, serum Cys C level and scleroma subsidence time were obviously lowered in moderate-severe SN chil- dren patients and mild SN children patients of the treatment group (P <0. 05), but with no statistical difference in serum level of BUN or Cr (P >0. 05). Conclusions Serum Cys C level could reflect early renal injury in SN children patients. But LI could obviously reduce serum Cys C level, promote the recovery of renal injury of SN neonates, and shorten scleroma subsidence time.

摘要

目的观察川芎嗪注射液（LI）对新生儿硬肿症（SN）患儿血清胱抑素C（Cys C）水平的影响。方法选取69例SN患儿作为SN组，其中轻度SN患儿39例，中重度SN患儿30例。另选取30例新生儿作为对照组。根据随机数字表将轻度SN患儿和中重度SN患儿分别分为治疗组和常规组。常规组患儿接受常规支持治疗及对症治疗，治疗组患儿在此基础上额外注射LI（6 mg/kg，加入30 mL 5%葡萄糖注射液中；每日1次）。所有治疗均持续7天。检测血清Cys C、血尿素氮（BUN）及肌酐（Cr）水平。分别计算Cys C、BUN及Cr的异常率，并分析它们之间的相关性。同时观察每组患儿硬肿消退时间。结果 SN组患儿血清Cys C水平明显高于对照组（t =10. 55，P <0. 01）。对照组与SN组患儿血清BUN及Cr水平比较，差异无统计学意义（t =1.50，1. 73；P >0. 05）。中重度SN患儿血清Cys C水平明显高于轻度SN患儿（t =2. 11，P <0. 05）；中重度SN患儿和轻度SN患儿血清BUN及Cr水平呈升高趋势，但差异无统计学意义（t =2. 07，1. 92；P >0. 05）。直线相关分析显示，SN组患儿血清Cys C水平分别与血清BUN水平及血清Cr水平呈正相关（r =0. 314，0. 287，P <0. 05）。血清Cys C、BUN及Cr的异常率分别为72. 5%（50/69）、27. 5%（19/69）和36. 2%（25/69）。血清Cys C的异常率明显高于BUN或Cr（x² =41. 04；P <0. 01）。与常规组比较，治疗组中重度SN患儿和轻度SN患儿血清Cys C水平及硬肿消退时间明显降低（P <0. 05），但血清BUN及Cr水平差异无统计学意义（P >0. 05）。结论血清Cys C水平可反映SN患儿早期肾损伤。但LI可明显降低血清Cys C水平，促进SN新生儿肾损伤的恢复，并缩短硬肿消退时间。