Legius Barbara, Nackaerts Kristiaan
Department of Pulmonology, Respiratory Oncology Unit, University Hospitals Leuven, UZ Leuven, Herestraat 49, 3000 Leuven, Belgium.
Lung Cancer Manag. 2017 Dec;6(3):87-91. doi: 10.2217/lmt-2017-0016. Epub 2017 Dec 1.
Thromboembolic events (TEEs) are frequent in cancer patients, especially venous thrombosis. Arterial thrombosis is less frequent. Chemotherapy increases the risk of these TEEs. Although TEEs are often reported, intestinal ischemia is a rare complication in cancer patients treated with chemotherapy. Here we describe a rare case of a patient with small cell lung cancer, who developed intestinal ischemia during treatment with cisplatin-etoposide chemotherapy. Shock and multiple organ failure developed and an urgent laparotomy with total colectomy was necessary. This case and review of the literature show that overall arterial TEEs are not as infrequent and may rarely manifest as intestinal ischemia. A cardiovascular assessment before the start of anticancer therapy is therefore imperative for cancer patients.
血栓栓塞事件（TEEs）在癌症患者中很常见，尤其是静脉血栓形成。动脉血栓形成则较少见。化疗会增加这些TEEs的风险。尽管TEEs经常被报道，但在接受化疗的癌症患者中，肠缺血是一种罕见的并发症。在此，我们描述了一例罕见病例，一名小细胞肺癌患者在接受顺铂-依托泊苷化疗期间发生了肠缺血。出现了休克和多器官功能衰竭，因此有必要进行紧急剖腹手术并全结肠切除术。该病例及文献回顾表明，总体而言动脉TEEs并非不常见，且可能很少表现为肠缺血。因此，对于癌症患者来说，在开始抗癌治疗前进行心血管评估势在必行。
