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肥厚性硬脑膜炎作为肉芽肿性多血管炎的一种重要神经系统并发症。

Hypertrophic pachymeningitis as an important neurological complication of granulomatosis with polyangiitis.

作者信息

Smoleńska Żaneta, Masiak Anna, Zdrojewski Zbigniew

机构信息

Clinic of Internal Medicine, Connective Tissue Diseases, and Geriatrics, Medical University of Gdańsk, Poland.

出版信息

Reumatologia. 2018;56(6):399-405. doi: 10.5114/reum.2018.80719. Epub 2018 Dec 23.

DOI:10.5114/reum.2018.80719
PMID:30647488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6330683/
Abstract

Headache is a common symptom in patients with granulomatosis with polyangiitis (GPA) mainly due to chronic sinusitis or orbital disease. Meningeal involvement may thus remain unrecognized for a long time. This can lead to a significant delay in accurate diagnosis, serious local damage of the central nervous system and high relapse rates. New diagnostic techniques such as contrast MRI allow one to identify inflammation of the dura mater in the course of GPA more frequently. The objective of this article is to characterize hypertrophic pachymeningitis (HP) in patients with GPA and report diagnostic difficulties associated with this complication.

摘要

头痛是肉芽肿性多血管炎（GPA）患者的常见症状，主要由慢性鼻窦炎或眼眶疾病引起。因此，脑膜受累可能长期未被识别。这可能导致准确诊断的显著延迟、中枢神经系统的严重局部损伤以及高复发率。诸如对比增强磁共振成像等新的诊断技术使人们能够更频繁地识别GPA病程中的硬脑膜炎症。本文的目的是描述GPA患者的肥厚性硬脑膜炎（HP）并报告与此并发症相关的诊断困难。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7673/6330683/9893ad63ae01/RU-56-80719-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7673/6330683/862146441320/RU-56-80719-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7673/6330683/9893ad63ae01/RU-56-80719-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7673/6330683/862146441320/RU-56-80719-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7673/6330683/9893ad63ae01/RU-56-80719-g002.jpg

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