1 Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
2 Biomaterials Nanotechnology and Tissue Engineering Group, Department of Advanced Medical Technology, Isfahan University of Medical Sciences, Isfahan, Iran.
Tissue Eng Part B Rev. 2019 Jun;25(3):202-224. doi: 10.1089/ten.TEB.2018.0245.
Scaffolds fabricated from extracellular matrix (ECM) derivatives are composed of conducive structures for cell attachment, proliferation, and differentiation, but generally do not have proper mechanical properties and load-bearing capacity. In contrast, scaffolds based on synthetic biomaterials demonstrate appropriate mechanical strength, but the absence of desirable biological properties is one of their main disadvantages. To integrate mechanical strength and biological cues, these ECM derivatives can be conjugated with synthetic biomaterials. Hence, hybrid scaffolds comprising both advantages of synthetic polymers and ECM derivatives can be considered a robust vehicle for tissue engineering applications.
由细胞外基质 (ECM) 衍生物制成的支架具有有利于细胞附着、增殖和分化的结构，但通常不具有适当的机械性能和承载能力。相比之下，基于合成生物材料的支架具有适当的机械强度，但缺乏理想的生物特性是它们的主要缺点之一。为了整合机械强度和生物信号，这些 ECM 衍生物可以与合成生物材料结合。因此，包含合成聚合物和 ECM 衍生物两者优势的混合支架可以被认为是组织工程应用的强大载体。
