Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada; Heart Institute, Hadassah-Hebrew University Medical Centre, Jerusalem, Israel.
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.
Resuscitation. 2019 Mar;136:1-7. doi: 10.1016/j.resuscitation.2019.01.010. Epub 2019 Jan 14.
Although the prevention and treatment of cardiovascular conditions have significantly improved over the past decade, whether they have reduced the incidence of sudden cardiac death (SCD) is not known. We sought to evaluate the temporal trends of SCD in a large unselected population.
We conducted a population-based cohort study using multiple linked longitudinal data in Ontario Canada. We included patients aged 35-74 years who had SCD from April 1st 2003 to March 31st 2014. SCD was defined as those who died of cardiac causes outside of the hospital or the emergency department, and had no recent hospitalization, no serious illness, and who were not residing in long-term care facilities.
We identified 36,334 patients who fulfilled criteria for SCD. The overall age and sex-standardized rate of SCD declined from 57.9/100,000 in fiscal year 2003 to 42.4/100,000 in 2013. Men and women had similar declining trends in SCD incidence. Larger reductions were seen among the older age groups. Patients who had prior heart failure experienced the largest decline in SCD incidence from 829/100,000 to 533/100,000 from 2003 to 2013. Patients who had prior myocardial infarction also had significant reduction from 484/100,000 to 381/100,000. In contrast, individuals with cardiac risk factors without disease had much smaller declines in SCD incidence.
Although significant progress to reduce SCD among patients with cardiac conditions was made in the past decade, additional effort should focus on the prevention of SCD in individuals without heart disease.
尽管在过去十年中,心血管疾病的预防和治疗有了显著改善,但它们是否降低了心源性猝死(SCD)的发生率尚不清楚。我们试图评估在一个大型未选择人群中心源性猝死的时间趋势。
我们在加拿大安大略省进行了一项基于人群的队列研究,使用了多个纵向链接数据。我们纳入了年龄在 35-74 岁之间的患者,他们在 2003 年 4 月 1 日至 2014 年 3 月 31 日期间发生 SCD。SCD 定义为在医院或急诊室外死于心脏原因,且近期无住院、无严重疾病,且不在长期护理机构居住的患者。
我们确定了 36334 名符合 SCD 标准的患者。总体年龄和性别标准化 SCD 发生率从 2003 财年的 57.9/100,000 下降到 2013 年的 42.4/100,000。男性和女性的 SCD 发病率呈相似的下降趋势。年龄较大的人群降幅更大。有既往心力衰竭的患者 SCD 发病率从 2003 年的 829/100,000 降至 2013 年的 533/100,000,降幅最大。有既往心肌梗死的患者也从 484/100,000 降至 381/100,000,降幅显著。相比之下,无心脏病但有心脏危险因素的个体 SCD 发病率下降幅度较小。
尽管在过去十年中,患有心脏疾病的患者的 SCD 显著减少,但还应将更多的精力集中在预防无心脏病的个体的 SCD 上。