比较不同预测模型在膀胱癌特异性生存预测中的应用。
Comparison of different prognostic models for predicting cancer-specific survival in bladder transitional cell carcinoma.
机构信息
Department of Urology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450014, Henan Province, PR China.
Department of Emergency Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, Guangdong Province, PR China.
出版信息
Future Oncol. 2019 Mar;15(8):851-864. doi: 10.2217/fon-2018-0695. Epub 2019 Jan 18.
OBJECTIVE
To construct the newly valuable nomogram which can compare the predictive performance with American Joint Committee on Cancer (AJCC) staging system in bladder transitional cell carcinoma (BTCC).
METHODS
BTCC patients were screened (2004-2015) from the SEER database. The nomogram incorporating lymph node ratio was constructed to evaluate individualized cancer-specific survival.
RESULTS
The C-index of the nomogram for predicting cancer-specific survival was 0.743 (95% CI: 0.720-0.766), which was higher than C-index of the AJCC staging system.
CONCLUSION
Lymph node ratio can be a reliable prognostic indicator for BTCC. The proposed nomogram showed more satisfactory predictive accuracy and wider applicability than current AJCC staging system in individualized prediction of BTCC patients.
目的
构建新的有价值的列线图，以比较其在膀胱癌（BTCC）中的预测性能与美国癌症联合委员会（AJCC）分期系统。
方法
从 SEER 数据库中筛选 BTCC 患者（2004-2015 年）。构建列线图，纳入淋巴结比值，以评估个体化癌症特异性生存。
结果
预测癌症特异性生存的列线图的 C 指数为 0.743（95%CI：0.720-0.766），高于 AJCC 分期系统的 C 指数。
结论
淋巴结比值可作为 BTCC 的可靠预后指标。与当前的 AJCC 分期系统相比，所提出的列线图在个体化预测 BTCC 患者方面显示出更高的预测准确性和更广泛的适用性。
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