肌肉功能丧失与胃肠道癌症患者的焦虑有关。
Muscle function loss is associated with anxiety in patients with gastrointestinal cancer.
作者信息
Soares Jéssika D P, Gomes Tatyanne L N, Siqueira Jéssika M, Oliveira Izabella C L, Mota Joao F, Laviano Alessandro, Pimentel Gustavo D
机构信息
Laboratory of Research in Clinical Nutrition and Sports (Labince), Faculty of Nutrition, Federal University of Goiás, Goiânia, GO, Brazil.
Department of Clinical Medicine, Sapienza University, Viale dell'Università 37, 00185, Rome, Italy.
出版信息
Clin Nutr ESPEN. 2019 Feb;29:149-153. doi: 10.1016/j.clnesp.2018.11.003. Epub 2018 Nov 22.
OBJECTIVE
To verify the prevalence of patients with muscle function loss (MFL) and whether it is associated with anxiety and depression scores in gastrointestinal (GI) cancer patients.
METHODS
A cross-sectional study with seventy-one adult GI cancer patients was conducted. The MFL was evaluated by the SARC-F questionnaire, and participants were divided into MFL (cut-off ≥4 SARC-F) and normal muscle function (NMF) groups (cut-off <4 SARC-F). Anxiety and depression were analyzed using the Hospital Anxiety and Depression Scale (HADS).
RESULTS
From 71 patients, 25.4% (n = 18) were classified as MFL and 74.6% (n = 53) as NMF. Body weight was lower in the MFL group when compared to the NMF group (MFL: 57.6 ± 11.3 vs. NMF: 64.8 ± 11.6 kg, p = 0.032). MFL showed higher anxiety (MFL: 7.5 (0-21) vs. NMF: 2 (0-17), p = 0.030) and depression scores (MFL: 6.5 (0-13) vs. NMF: 2 (0-17), p = 0.034) compared to NMF. A positive correlation between the SARC-F and the anxiety (r = 0.34, p = 0.004) and depression score (r = 0.32, p = 0.006) was found. When adjusted by sex and body weight, MFL saw an increase with the anxiety score (OR: 1.15 95%CI(1.01-1.31), p = 0.023), but not with the depression score. In addition, LMF was responsible for anxiety in 12% of the population.
CONCLUSION
In our study, 25% of GI cancer patients presented LMF and an association with the anxiety score.
目的
验证胃肠（GI）癌患者中肌肉功能丧失（MFL）患者的患病率，以及其是否与焦虑和抑郁评分相关。
方法
对71名成年GI癌患者进行了一项横断面研究。通过SARC-F问卷评估MFL，参与者被分为MFL组（临界值≥4分的SARC-F）和正常肌肉功能（NMF）组（临界值<4分的SARC-F）。使用医院焦虑抑郁量表（HADS）分析焦虑和抑郁情况。
结果
71名患者中，25.4%（n = 18）被归类为MFL，74.6%（n = 53）为NMF。与NMF组相比，MFL组的体重更低（MFL：57.6±11.3 vs. NMF：64.8±11.6 kg，p = 0.032）。与NMF相比，MFL表现出更高的焦虑（MFL：7.5（0 - 21）vs. NMF：2（0 - 17），p = 0.030）和抑郁评分（MFL：6.5（0 - 13）vs. NMF：2（0 - 17），p = 0.034）。发现SARC-F与焦虑（r = 0.34，p = 0.004）和抑郁评分（r = 0.32，p = 0.006）之间存在正相关。在按性别和体重进行调整后，MFL随焦虑评分增加（OR：1.15 95%CI（1.01 - 1.31），p = 0.023），但与抑郁评分无关。此外，LMF导致12%的人群出现焦虑。
结论
在我们的研究中，25%的GI癌患者存在LMF，且与焦虑评分相关。
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