Swavely Natalie R, Anele Uzoma A, Porpiglia Francesco, Mir Maria C, Hampton Lance J, Autorino Riccardo
Department of Surgery, VCU Health, Richmond, VA, USA Department of Surgery, McGuire VA Medical Center, Richmond, VA, USA.
Department of Urology, University of Turin, Orbassano, Italy.
Ther Adv Urol. 2019 Jan 8;11:1756287218815819. doi: 10.1177/1756287218815819. eCollection 2019 Jan-Dec.
Over the past few years, the role of robotic-assisted partial nephrectomy (RPN) has exponentially grown. Multiple recognized factors contribute to postoperative renal function in patients undergoing RPN. The aim of this review is to identify these potential factors, and to evaluate strategies that may help optimize the goal of renal function preservation. A nonsystematic literature review was performed to retrieve the most recent evidence on factors contributing to renal function post-RPN. Analyzed elements include baseline factors (tumor complexity and patient characteristics), intraoperative (surgical) factors (control of the renal hilum and type of ischemia, resection technique, renorrhaphy technique), and pharmacotherapeutics. In conclusion, the advantages of robotic surgery in the setting of partial nephrectomy (PN) are becoming well established. Maximal preservation of renal function remains a priority goal of the procedure, and it is influenced by a plethora of factors. Adequate patient selection using radiomics, control of comorbidities, utilization of evidence-based intraoperative techniques/strategies, and postoperative care are key components of postoperative preservation of renal function. Further investigations regarding these factors and their effects on long-term renal function are necessary and will continue to aid in guiding appropriate patient care.
在过去几年中,机器人辅助部分肾切除术(RPN)的作用呈指数级增长。多种公认的因素影响接受RPN患者的术后肾功能。本综述的目的是确定这些潜在因素,并评估可能有助于优化肾功能保留目标的策略。进行了非系统性文献综述,以检索有关RPN后影响肾功能因素的最新证据。分析的要素包括基线因素(肿瘤复杂性和患者特征)、术中(手术)因素(肾门控制和缺血类型、切除技术、肾缝合技术)以及药物治疗。总之,机器人手术在部分肾切除术(PN)中的优势已得到充分确立。最大限度地保留肾功能仍然是该手术的首要目标,并且它受到众多因素的影响。使用放射组学进行充分的患者选择、控制合并症、采用循证术中技术/策略以及术后护理是术后保留肾功能的关键组成部分。关于这些因素及其对长期肾功能影响的进一步研究是必要的,并且将继续有助于指导适当的患者护理。