Perdigoto David N, Tomé Luís, Diogo Dulce, Ferrão José, Martins Ricardo, Oliveira Pedro, Tralhão Guilherme, Furtado Emanuel
Gastroenterology Department, Coimbra University and Hospital Centre, Coimbra, Portugal.
Adult and Paediatric Liver Transplantation Unit, Coimbra University and Hospital Centre, Coimbra, Portugal.
GE Port J Gastroenterol. 2018 Dec;26(1):54-58. doi: 10.1159/000487155. Epub 2018 Mar 7.
Acute liver failure is an uncommon condition associated with a high mortality. Most patients do not survive without liver transplantation. In the last decades, auxiliary liver transplantation has emerged as a therapeutic option.
The authors present two cases of acute liver failure that required liver transplantation. Given the patients' young age and the preserved macroscopic liver pattern evaluated in surgery, auxiliary liver transplantation was executed using different surgical approaches. Afterwards, following confirmed full native liver regeneration, the patients were submitted to auxiliary liver hepatectomy, which was accomplished without complications.
Auxiliary liver transplantation can be regarded as an effective temporary treatment for acute liver failure in selected cases, allowing an immunosuppression-free life.
急性肝衰竭是一种不常见的疾病,死亡率很高。大多数患者若不进行肝移植则无法存活。在过去几十年中,辅助性肝移植已成为一种治疗选择。
作者介绍了两例需要进行肝移植的急性肝衰竭病例。鉴于患者年轻且手术中评估的肝脏大体形态保存完好,采用了不同的手术方法进行辅助性肝移植。之后,在确认原生肝脏完全再生后,对患者进行了辅助性肝脏肝切除术,手术完成且无并发症。
辅助性肝移植可被视为某些特定急性肝衰竭病例的有效临时治疗方法,能让患者在无免疫抑制的情况下生活。