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白细胞介素-6 与肌萎缩侧索硬化症。

Interleukin-6 and amyotrophic lateral sclerosis.

机构信息

Institute of Physiology and Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Portugal.

Institute of Physiology and Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Portugal; Barts and the London School of Medicine, Queen Mary University of London, United Kingdom.

出版信息

J Neurol Sci. 2019 Mar 15;398:50-53. doi: 10.1016/j.jns.2019.01.026. Epub 2019 Jan 16.

Abstract

BACKGROUND

IL-6 is an inflammatory cytokine that is a possible factor in progression of the disease. We have investigated venous blood levels of IL-6 in controls and ALS patients in relation to clinical staging and respiratory function.

METHODS

We studied 82 patients with ALS and 43 age and gender-matched healthy control subjects. Blood was drawn at the same time of day in the mornings to avoid diurnal variation. IL-6 levels were estimated according to a fixed protocol. Clinical measures included ALSFRS-R, vital capacity, and mean bilateral phrenic nerve CMAP amplitude. A multi-regression data analysis was used in addition to conventional statistical methods.

RESULTS

IL-6 levels were positively correlated with increasing age in the control group. In ALS patients mean IL-6 levels were raised but the levels were markedly variable from case to case and did not reach significance (p 0.1). In addition to age effects reduction in phrenic nerve CMAP amplitude was correlated with increased IL-6 levels (p 0.026).

CONCLUSIONS

IL-6 levels were physiologically influenced by aging in controls and by respiratory dysfunction in ALS. There was marked variability in levels from case to case, which might be related to respiratory factors, which cause pulmonary inflammation.

摘要

背景

IL-6 是一种炎症细胞因子,可能是疾病进展的一个因素。我们研究了对照组和 ALS 患者的静脉血 IL-6 水平与临床分期和呼吸功能的关系。

方法

我们研究了 82 例 ALS 患者和 43 名年龄和性别匹配的健康对照组。为避免昼夜变化,在早晨同一时间抽取血液。根据固定方案估计 IL-6 水平。临床指标包括 ALSFRS-R、肺活量和双侧膈神经 CMAP 振幅的平均值。除了常规统计学方法外,还使用了多元回归数据分析。

结果

对照组中 IL-6 水平与年龄呈正相关。在 ALS 患者中,平均 IL-6 水平升高,但个体间差异很大,未达到显著性(p>0.1)。除了年龄的影响,膈神经 CMAP 振幅的降低与 IL-6 水平的升高相关(p=0.026)。

结论

在对照组中,IL-6 水平受年龄的生理影响,在 ALS 中受呼吸功能障碍的影响。个体间水平差异很大,可能与引起肺部炎症的呼吸因素有关。

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