MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou 350108, China; Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, USA; Department of Polymer Science and Technology, School of Chemical Engineering and Technology, Key Laboratory of Systems Bioengineering of the Ministry of Education, Tianjin University, Tianjin 300072, China.
Department of Polymer Science and Technology, School of Chemical Engineering and Technology, Key Laboratory of Systems Bioengineering of the Ministry of Education, Tianjin University, Tianjin 300072, China.
J Control Release. 2019 Mar 10;297:60-70. doi: 10.1016/j.jconrel.2019.01.026. Epub 2019 Jan 23.
Injectable in situ thermosensitive hydrogels have potential applications in tissue engineering and drug delivery. The hydrogel formulations exist as aqueous solutions at room temperature but rapidly solidify into gels at 37 °C in situ, making them highly suitable for administering drugs in a minimally invasive manner to the target organ(s). The hydrogel formed with nanoparticles assembled with amphiphilic polymer blocks of polyethyleneglycol (PEG) and biodegradable polycaprolactone (PCL) have been tested as platforms for targeted and sustained drug delivery, and have shown encouraging results. In this review, we summarize the influence of the molecular weight, PEG/PCL ratio and functional structure of hydrophobic PCL blocks on the critical gelation temperature, gelling behavior and drug release kinetics of the hydrogels. The current studies on the biomedical applications of thermosensitive PEG/PCL hydrogels have also been discussed.
可注射原位温敏水凝胶在组织工程和药物输送中有潜在的应用。水凝胶制剂在室温下为水溶液，但在 37°C 时迅速原位凝固成凝胶，非常适合以微创方式将药物递送到目标器官。由具有两亲性聚合物嵌段的聚乙二醇（PEG）和可生物降解的聚己内酯（PCL）的纳米粒子组装而成的水凝胶已被测试为靶向和持续药物输送的平台，并显示出令人鼓舞的结果。在这篇综述中，我们总结了疏水性 PCL 嵌段的分子量、PEG/PCL 比和功能结构对水凝胶的临界胶凝温度、胶凝行为和药物释放动力学的影响。还讨论了温敏 PEG/PCL 水凝胶在生物医学中的应用的当前研究。
