Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
Oxford Musculoskeletal Biomedical Research Unit, National Institute for Health Research, Oxford, United Kingdom.
Front Immunol. 2019 Jan 10;9:3132. doi: 10.3389/fimmu.2018.03132. eCollection 2018.
Susceptibility to ankylosing spondylitis (AS) is polygenic with more than 100 genes identified to date. These include and the aminopeptidases (, and ), which are involved in antigen processing and presentation to T-cells, and several genes (, and ) involved in IL23 driven pathways of inflammation. AS is also strongly associated with polymorphisms in two transcription factors, RUNX3 and T-bet (encoded by ), which are important in T-cell development and function. The influence of these genes on the pathogenesis of AS and their potential for identifying drug targets is discussed here.
强直性脊柱炎（AS）易感性具有多基因性，迄今为止已确定超过 100 个基因。这些基因包括肽基二肽酶（、和），它们参与抗原加工和呈递给 T 细胞，以及几个参与 IL23 驱动炎症途径的基因（、和）。AS 还与两个转录因子 RUNX3 和 T-bet（由编码）的多态性强烈相关，它们在 T 细胞发育和功能中很重要。本文讨论了这些基因对 AS 发病机制的影响及其作为药物靶点的潜力。
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