Department of Medical Microbiology, Medical University of Lublin, 20-093 Lublin, W. Chodźki 1, Poland.
Chair and Department of Dermatology, Venerology and Paediatric Dermatology, Medical University of Lublin, 20-080 Lublin, Radziwiłłowska 13, Poland.
J Immunol Res. 2018 Dec 31;2018:1691347. doi: 10.1155/2018/1691347. eCollection 2018.
is a microorganism that may cause a serious threat in postsplenectomy patients due to a potentially invasive course of infection. In order to assess a protective activity after vaccination with the 23-valent vaccine, we made an analysis of the level of antibodies in patients with asplenia compared to a control group of healthy donors. Additionally, colonization by potentially pathogenic microorganisms of the upper respiratory tract was analyzed to determine the carrier state by strains with vaccine serotype. No such strains were found in the research, yet three non-vaccine-serotype strains were found. Colonization of the upper respiratory tract by potentially pathogenic microorganisms may be connected with increased susceptibility observed and incidence of infections in patients with asplenia. However, colonization by may not have an effect on the level of specific antibodies with the 23-valent vaccine against (PPV23) in postsplenectomy patients and healthy people. The response to vaccination against showed a lower level of specific antibodies in patients with splenectomy performed more than 2 years before the test than in patients with a recently removed spleen, i.e., from 1 month to 2 years before the test. Vaccination against pneumococci also has positive effects on incidence of other etiology infections, which is of high significance in the prophylaxis of infectious diseases in this group of patients.
是一种微生物，由于感染的潜在侵袭性过程，可能对脾切除术后患者构成严重威胁。为了评估 23 价疫苗接种后的保护活性，我们分析了脾切除患者与健康对照组的抗体水平。此外，还分析了上呼吸道潜在致病性微生物的定植情况，以确定具有疫苗血清型的菌株的携带状态。研究中未发现此类菌株，但发现了三种非疫苗血清型菌株。上呼吸道潜在致病性微生物的定植可能与脾切除患者观察到的易感性增加和感染发生率有关。然而， 定植可能不会对上呼吸道定植的影响。在脾切除患者和健康人群中，23 价疫苗（PPV23）针对 的特异性抗体水平。与脾切除术 2 年以上前接受测试的患者相比，脾切除术 1 个月至 2 年前接受测试的患者对肺炎球菌的疫苗接种反应显示出较低水平的特异性抗体。针对肺炎球菌的疫苗接种也对其他病因感染的发生率产生积极影响，这对预防该患者群体的传染病具有重要意义。
