Development. 2019 Jan 28;146(2):dev175851. doi: 10.1242/dev.175851.
The molecular regulation of pluripotency has been most intensively studied in early mammalian development, but whether the transcriptional networks revealed in mouse and man also regulate pluripotency in other deuterostomes has remained unclear. A paper in this issue of Development now addresses the evolution of pluripotency with an analysis of the function of PRDM14 in zebrafish, amphioxus and sea urchin. We caught up with first authors Masanori Kawaguchi and Kota Sugiyama and their supervisor Yoshiyuki Seki, Associate Professor at Kwansei Gakuin University in Sanda, Japan, to find out more about the story.
多能性的分子调控在早期哺乳动物发育中得到了最深入的研究,但在其他后口动物中,在小鼠和人类中揭示的转录网络是否也调节多能性仍然不清楚。本期《发育》杂志的一篇论文通过分析 PRDM14 在斑马鱼、文昌鱼和海胆中的功能,探讨了多能性的进化。我们采访了第一作者 Kawaguchi Masanori 和 Kota Sugiyama 以及他们的导师日本神户学院大学的副教授 Seki Yoshiyuki,以了解更多相关信息。