用选择性多巴胺D-1受体拮抗剂SCH 23390进行长期治疗，可降低大鼠尾状核中的多巴胺代谢。

Chronic treatment with SCH 23390, a selective dopamine D-1 receptor antagonist, decreases dopamine metabolism in rat caudate nucleus.

作者信息

Koulu M, Lappalainen J, Pesonen U, Hietala J, Syvälahti E

机构信息

Department of Pharmacology, University of Turku, Finland.

出版信息

Eur J Pharmacol. 1988 Oct 18;155(3):313-6. doi: 10.1016/0014-2999(88)90521-3.

DOI:10.1016/0014-2999(88)90521-3

PMID:3069483

Abstract

Chronic treatment (18 days; 0.1 and 0.5 mg/kg per day) with the selective dopamine (DA) D-1 receptor antagonist, SCH 23390, significantly reduced the concentration of homovanillic acid (HVA) and the ratios of HVA/DA and DOPAC/DA in the nucleus caudatus of the rat but did not change the metabolism of DA in the prefrontal cortex, substantia nigra or the A10 area. Furthermore, the concentrations of noradrenaline were dose dependently decreased in the A10 area during SCH 23390 treatment. It is concluded that chronic DA D-1 receptor blockade causes changes in the metabolism of DA similar to those caused by classical neuroleptics.

摘要

用选择性多巴胺（DA）D - 1受体拮抗剂SCH 23390进行慢性治疗（18天；每天0.1和0.5毫克/千克），可显著降低大鼠尾状核中高香草酸（HVA）的浓度以及HVA/DA和DOPAC/DA的比值，但不会改变前额叶皮质、黑质或A10区中DA的代谢。此外，在SCH 23390治疗期间，A10区去甲肾上腺素的浓度呈剂量依赖性降低。结论是，慢性DA D - 1受体阻断导致DA代谢变化，类似于经典抗精神病药物所引起的变化。