Cho Seong-Sik, Ju Young-Su, Park Hanwool, Kim Young-Kug, Hwang Shin, Choi Seong-Soo
Department of Occupational and Environmental Medicine, Hallym University Sacred Heart Hospital, Anyang.
Department of Anesthesiology and Pain Medicine, Asan Medical Center.
Medicine (Baltimore). 2019 Feb;98(5):e13979. doi: 10.1097/MD.0000000000013979.
Among living donor liver transplantation recipients, the impact of educational levels on survival has rarely explored. Thus, the purpose of study is to analyze the survival rate differences across educational levels among recipients who underwent living donor liver transplantation.We retrospectively analyzed 2007 adult recipients who underwent living donor liver transplantation in a single large center. The educational level was divided into three categories: middle school or lower, high school, and college or higher. The primary outcome was all-cause mortality after living donor liver transplantation. Stratified log-rank test and Cox proportional hazard model were employed for statistical analysis.The incidence rates of all-cause mortality were 23.85, 20.19, and 18.75 per 1000 person-year in recipients with middle school or lower, high school, and college or higher education groups, respectively. However, the gender-stratified log-rank test has not shown a statistically significant difference (P = .3107). In the unadjusted model, hazard ratio (HR) was 1.02 [95% confidence interval (CI) = 0.79-1.33] in high school and 1.23 (95% CI = 0.93-1.64) and in middle school or lower educational level, respectively; In the full adjusted model, the HR of high school was 0.98 (95% CI = 0.75-1.28) and the HR of middle school or lower was 1.01 (95% CI = 0.74-1.37).Although study population of this study is large, we could not find significant survival rate differences by the levels of education. Social selection and high compliance rate might contribute to this result.
在活体肝移植受者中,教育水平对生存的影响鲜有研究。因此,本研究的目的是分析接受活体肝移植的受者中不同教育水平的生存率差异。我们回顾性分析了在一个大型单一中心接受活体肝移植的2007例成年受者。教育水平分为三类:初中及以下、高中、大专及以上。主要结局是活体肝移植后的全因死亡率。采用分层对数秩检验和Cox比例风险模型进行统计分析。初中及以下、高中、大专及以上教育水平组的受者全因死亡率发生率分别为每1000人年23.85、20.19和18.75例。然而,按性别分层的对数秩检验未显示出统计学上的显著差异(P = 0.3107)。在未调整模型中,高中教育水平组的风险比(HR)为1.02 [95%置信区间(CI)= 0.79 - 1.33],初中及以下教育水平组的HR为1.23(95% CI = 0.93 - 1.64);在完全调整模型中,高中教育水平组的HR为0.98(95% CI = 0.75 - 1.28),初中及以下教育水平组的HR为1.01(95% CI = 0.74 - 1.37)。尽管本研究的样本量很大,但我们未发现不同教育水平之间存在显著的生存率差异。社会选择和高依从率可能导致了这一结果。