Institut de Recherche en Santé Digestive, Université de Toulouse, Institut National de la Santé et de la Recherche Médicale, Institut National de la Recherche Agronomique, Ecole Nationale Vétérinaire de Toulouse, Université Paul Sabatier, Toulouse, France.
Laboratoire Inflamex, Université Paris-Diderot Sorbonne Paris-Cité, Paris, France; INSERM, UMR 1149, Paris, France.
Cell Mol Gastroenterol Hepatol. 2019;7(2):357-369. doi: 10.1016/j.jcmgh.2018.10.009. Epub 2018 Oct 23.
Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular pattern recognition receptor that senses bacterial peptidoglycan-conserved motifs in cytosol and stimulates host immune response including epithelial and immune cells. The association of NOD2 mutations with a number of inflammatory pathologies including Crohn's disease (CD), graft-versus-host diseases, or Blau syndrome, highlights its pivotal role in inflammatory response and the associated-carcinogenesis development. Since its identification in 2001 and its association with CD, the role of NOD2 in epithelial cells and immune cells has been investigated extensively but the precise mechanism by which NOD2 mutations lead to CD and the associated carcinogenesis development is largely unknown. In this review, we present and discuss recent developments about the role of NOD2 inside epithelial cells on the control of the inflammatory process and its linked carcinogenesis development.
核苷酸结合寡聚化结构域 2（NOD2）是一种细胞内模式识别受体，可在细胞质中感应细菌肽聚糖保守基序，并刺激包括上皮细胞和免疫细胞在内的宿主免疫反应。NOD2 突变与许多炎症性疾病（包括克罗恩病、移植物抗宿主病或布劳综合征）相关，这突出了其在炎症反应和相关致癌发展中的关键作用。自 2001 年被发现并与 CD 相关联以来，NOD2 在肠上皮细胞和免疫细胞中的作用已被广泛研究，但 NOD2 突变导致 CD 和相关致癌发展的确切机制在很大程度上尚不清楚。在这篇综述中，我们介绍并讨论了 NOD2 在控制炎症过程及其相关致癌发展方面在上皮细胞内的作用的最新进展。
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