在新生儿重症监护病房环境中，即时检验 C 反应蛋白与标准实验室测量 C 反应蛋白的比较。
A Comparison of Point of Care C-Reactive Protein Test to Standard C-Reactive Protein Laboratory Measurement in a Neonatal Intensive Care Unit Setting.
机构信息
Neonatal Medicine, Department of Paediatrics, University of Cape Town, Cape Town, South Africa.
Division of Chemical Pathology, University of Cape Town, Cape Town, South Africa.
出版信息
J Trop Pediatr. 2019 Oct 1;65(5):498-504. doi: 10.1093/tropej/fmy082.
BACKGROUND
Biomarkers assist in diagnosing neonatal sepsis but often provide results 6 to 48 h later. Bedside C-reactive protein (CRP) test may help to expedite clinical management. We assessed the performance of point of care test (POCT) CRP against routine laboratory analysis and determined the time difference in obtaining results.
METHODS
A prospective observational study was conducted over 4 months. Neonates clinically indicated, had CRP simultaneously tested using the POCT and laboratory assays.
RESULTS
Using similar decision cut-off values of 10 mg/l, POCT compared favourably to laboratory testing. The median times to POCT result was 4 min whereas laboratory results were entered at a median of 4.1 h (95th percentile 8 h) but only checked after 5.5 h (95th percentile 19.8 h).
CONCLUSIONS
POCT may be a quick and reliable method to determine CRP. It may rationalize antibiotic usage, allow for earlier patient discharge and reduce overall patient management cost.
背景
生物标志物有助于诊断新生儿败血症，但通常需要 6 至 48 小时才能得出结果。床边 C 反应蛋白（CRP）检测可能有助于加速临床管理。我们评估了即时检测（POCT）CRP 的性能与常规实验室分析，并确定了获得结果的时间差异。
方法
进行了为期 4 个月的前瞻性观察研究。对临床疑似的新生儿同时使用 POCT 和实验室检测进行 CRP 检测。
结果
使用相似的 10mg/L 决策截断值，POCT 与实验室检测相比具有优势。POCT 的中位数结果时间为 4 分钟，而实验室结果的中位数时间为 4.1 小时（95%分位数为 8 小时），但仅在 5.5 小时后（95%分位数为 19.8 小时）进行检查。
结论
POCT 可能是一种快速可靠的 CRP 检测方法。它可以合理化抗生素的使用，允许更早地出院，并降低整体患者管理成本。
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