P 物质与炎性疼痛：同时犯错与纠偏。
Substance P and Inflammatory Pain: Getting It Wrong and Right Simultaneously.
机构信息
Department of Pharmacology, University of Arizona, Tucson, AZ 85718, USA.
Department of Pharmacology, University of Arizona, Tucson, AZ 85718, USA; Mayo Clinic, Scottsdale, AZ 85259, USA.
出版信息
Neuron. 2019 Feb 6;101(3):353-355. doi: 10.1016/j.neuron.2019.01.034.
How do neuropeptides participate in the classic neuroinflammatory sequelae of tissue injury that includes pain, immune cell infiltration, and swelling? In this issue of Neuron, Green et al. (2019) reveal that MrgprB2/MrgprX2 is a mast cell substance-P-specific receptor that critically links neural and immune systems and offers new approaches for neuroinflammatory therapeutics.
神经肽如何参与包括疼痛、免疫细胞浸润和肿胀在内的经典神经炎症损伤后遗症？在本期《神经元》杂志上，Green 等人（2019）揭示了 MrgprB2/MrgprX2 是一种肥大细胞 P 物质特异性受体，它将神经系统和免疫系统紧密联系起来，并为神经炎症的治疗提供了新的方法。
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