腺样囊性癌患者血液学和炎症标志物的预处理评估：中性粒细胞/淋巴细胞比值与多次复发相关。
Pretreatment assessment of hematologic and inflammatory markers in adenoid cystic carcinoma: neutrophil/lymphocyte ratio is associated with multiple recurrences.
机构信息
Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria.
Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol. 2019 May;127(5):408-416. doi: 10.1016/j.oooo.2018.10.009. Epub 2018 Oct 30.
OBJECTIVE
Adenoid cystic carcinoma (ACC) is a rare entity of salivary gland cancer. Inflammatory and hematologic markers and their prognostic and predictive value have been intensively studied in several cancer entities. The aim of this study was to investigate the role of such markers in patients with ACC.
STUDY DESIGN
This retrospective analysis investigated hematologic and inflammatory markers in patients with ACC in the period between the years 1996 and 2016. We assessed the preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio, cross-reactive protein and fibrinogen levels. A total of 28 to 31 patients were included, depending on the examined parameter. All markers were evaluated for their effects on outcome and prognostic value.
RESULTS
Patients with an elevated preoperative NLR (>2) had a significantly higher multiple recurrence rate (44.4% vs 8.3%; P = .049). Other hematologic markers showed no significant effects on outcome.
CONCLUSIONS
This study showed that the NLR may serve as a useful prognosticator for a high risk of multiple recurrences in patients with ACC.
目的
腺样囊性癌（ACC）是一种罕见的唾液腺癌。在多种癌症实体中，炎症和血液标志物及其预后和预测价值已得到深入研究。本研究旨在探讨此类标志物在 ACC 患者中的作用。
研究设计
本回顾性分析调查了 1996 年至 2016 年间 ACC 患者的血液学和炎症标志物。我们评估了术前中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值、C 反应蛋白和纤维蛋白原水平。根据检查的参数，总共纳入了 28 至 31 例患者。所有标志物均评估了其对结局和预后价值的影响。
结果
术前 NLR（>2）升高的患者多次复发的风险显著更高（44.4%比 8.3%；P=0.049）。其他血液学标志物对结局无显著影响。
结论
本研究表明，NLR 可作为预测 ACC 患者多次复发高风险的有用指标。
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