一次一个细胞定义心脏中的巨噬细胞。
Defining Macrophages in the Heart One Cell at a Time.
机构信息
Department of Medicine, Marc and Ruti Bell Program for Vascular Biology and Disease, The Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, NY, USA.
Department of Medicine, Marc and Ruti Bell Program for Vascular Biology and Disease, The Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, NY, USA.
出版信息
Trends Immunol. 2019 Mar;40(3):179-181. doi: 10.1016/j.it.2019.01.010. Epub 2019 Feb 10.
Abstract
Macrophages in the heart have dual roles in injury and repair after myocardial infarction, and understanding the two sides of this coin using traditional 'bulk cell' technologies has been challenging. By combining genetic fate-mapping and single-cell transcriptomics, a new study (Nat. Immunol. 2019;20:29-39) reveals how distinct macrophage populations expand and diverge across the healthy heart and after infarction.
摘要
心肌梗死后，心脏中的巨噬细胞在损伤和修复中具有双重作用，使用传统的“批量细胞”技术理解这枚硬币的两面一直具有挑战性。一项新的研究（《自然免疫学》2019 年；20:29-39）结合遗传命运图谱和单细胞转录组学，揭示了不同的巨噬细胞群体在健康心脏和梗死后如何扩张和分化。
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